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Metastatic Castration-resistant Prostate Cancer Clinical Trials

Reviewed by TrialFinderData Editorial Team · Updated

12 recruiting trials for Metastatic Castration-resistant Prostate Cancer. Eligibility criteria explained in plain English.

TrialFinderData lists 12 Metastatic Castration-resistant Prostate Cancer clinical trials drawn from ClinicalTrials.gov, all of which are currently recruiting participants.

Across the trials that carry a phase, Phase 1 is the largest group at 27% (3 studies); the largest phase groups are Phase 1: 3, Phase 2: 3, Phase 1 / Phase 2: 3, Early Phase 1: 1.

Research is led by H. Lee Moffitt Cancer Center and Research Institute (1), Peking Union Medical College Hospital (1), Astellas Pharma Global Development, Inc. (1), among the most active sponsors registered for these trials.

The most frequently studied intervention is Enzalutamide (drug, 3 trials), followed by FOG-001, MSGV1-PSCA-8T28Z.

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.
12
Total Trials
12
Recruiting Now
1
Phase 3 Trials
10
Sponsors

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Recruiting Trials

Clinical trial data sourced from the ClinicalTrials.gov registry, maintained by the National Library of Medicine. Always consult your doctor before considering any clinical trial.

RECRUITINGPhase 1NCT06193486

Autologous Gamma Delta T Cells to Target Prostate Stem Cell Antigen in mCRPC

This is a phase 1 single center clinical trial for patients with end stage Metastatic Castration Resistant Prostate Cancer who have progressed through standard of care treatment...

Sponsor: H. Lee Moffitt Cancer Center and Research InstituteEnrolling: 301 location
RECRUITINGEarly Phase 1NCT05603559

177Lu-P17-087/177Lu-P17-088 in Patients With Metastatic Castration-resistant Prostate Cancer

This is a pilot study to assess the safety and measure image-based absorbed dose of 177Lu-P17-087/177Lu-P17-088 in patients with metastatic castration-resistant prostate cancer...

Sponsor: Peking Union Medical College HospitalEnrolling: 301 location
RECRUITINGPhase 2NCT07005154

A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer

Hormone therapy, or androgen deprivation therapy (ADT) is a standard way to treat prostate cancer. It works by reducing the amount of the main male sex hormone, testosterone in...

Sponsor: Astellas Pharma Global Development, Inc.Enrolling: 21820 locations
RECRUITINGPhase 2NCT06568562

XL092 in Patients With Metastatic Castration-Resistant Prostate Cancer

The purpose of this study is to determine how well the study drug XL092 is helping to treat a participant's cancer after 16 weeks of treatment. Researchers will also look at how...

Sponsor: University of UtahEnrolling: 321 location
RECRUITINGPhase 1NCT07545811

Study of JANX014 in Subjects With Metastatic Castration-Resistant Prostate Cancer

This study is a first-in-human, Phase 1, open-label, multicenter study to assess the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and the preliminary efficacy...

Sponsor: Janux TherapeuticsEnrolling: 431 location
RECRUITINGNCT06242509

Intestinal Akkermansia Muciniphila in Prostate Cancer

Prostate cancer has the highest incidence and is the second leading cause of cancer death in men in western countries. Androgen deprivation therapy is the backbone treatment....

Sponsor: Assistance Publique - Hôpitaux de ParisEnrolling: 521 location
RECRUITINGPhase 2NCT06922318

The COSMYC Trial (COmbined Suppression of MYC)

This research is being done to determine if receiving the combination of testosterone and ZEN-3694 followed by the combination of enzalutamide plus ZEN-3694 will decrease the size...

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsEnrolling: 501 location
RECRUITINGPhase 1NCT06492122

Study With [225Ac]Ac-FL-020 in mCRPC Participants

The purpose of this study is to evaluate the safety, therapeutic effect, and pharmacokinetics of \[225Ac\]Ac-FL-020 in participants with metastatic castration-resistant prostate...

Sponsor: Full-Life Technologies UK LimitedEnrolling: 5011 locations
RECRUITINGPhase 1 / Phase 2NCT05919264

FOG-001 in Locally Advanced or Metastatic Solid Tumors

The goal of this clinical trial is to determine if FOG-001 is safe and effective in participants with locally advanced or metastatic solid tumors.

Sponsor: Parabilis Medicines, Inc.Enrolling: 59520 locations
RECRUITINGPhase 1 / Phase 2NCT05125016

A Trial to Find Out if REGN4336 is Safe and How Well it Works Alone and in Combination With REGN5678 for Adult...

This study is researching an investigational drug called REGN4336 both alone or together with another investigational drug called REGN5678. The study is focused on participants...

Sponsor: Regeneron PharmaceuticalsEnrolling: 22814 locations
RECRUITINGPhase 1 / Phase 2NCT04104776

A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and Lymphomas

The purpose of this open-label, first-in-human (FIH) trial is to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of...

Sponsor: Novartis PharmaceuticalsEnrolling: 27520 locations
RECRUITINGPhase 3NCT06764485

A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator's Choice of Therapy in Participants...

The purpose of this study is to compare the efficacy and safety of BMS-986365 versus the investigator's choice of therapy in participants with Metastatic Castration-resistant...

Sponsor: CelgeneEnrolling: 96020 locations

Frequently Asked Questions

There are currently 12 clinical trials for Metastatic Castration-resistant Prostate Cancer, with 12 actively recruiting participants. These include trials across all phases from early-stage Phase 1 to late-stage Phase 3.

To join a clinical trial for Metastatic Castration-resistant Prostate Cancer, review the eligibility criteria on the trial detail pages, then talk to your doctor about whether a trial is right for you. Your doctor can help you evaluate the potential benefits and risks.

Phase 3 trials are large-scale studies that test whether a treatment is effective and monitor side effects. There are 1 Phase 3 trials for Metastatic Castration-resistant Prostate Cancer, representing treatments closest to potential FDA approval.

Clinical trials follow strict safety protocols overseen by Institutional Review Boards (IRBs) and the FDA. Participants are monitored closely and can withdraw at any time. Always discuss risks and benefits with your healthcare provider before enrolling.

Sources: ClinicalTrials.gov, FDA
Last updated:

Trial data sourced from the ClinicalTrials.gov API. This site does not provide medical advice, always talk to your doctor about clinical trial participation.