Alnylam Pharmaceuticals
4 clinical trials · 4 recruiting · INDUSTRY
Trials by Alnylam Pharmaceuticals
RECRUITINGNCT04561518
ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)
The purpose of this study is to: * Describe epidemiological and clinical characteristics, natural history and real-world clinical management of ATTR amyloidosis patients *...
Sponsor: Alnylam PharmaceuticalsEnrolling: 150020 locations
Transthyretin-Mediated AmyloidosisATTR Amyloidosis
RECRUITINGPhase 1NCT06585449
A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease
The purpose of this study is to evaluate the safety, tolerability, pharmacodynamics (PD) and pharmacokinetics (PK) of single or repeat doses of ALN-HTT02.
Sponsor: Alnylam PharmaceuticalsEnrolling: 6619 locations
Huntington's Disease
RECRUITINGPhase 1 / Phase 2NCT06845202
A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM
The purpose of this study is to: * evaluate the safety and tolerability of single ascending doses of ALN-4324 in healthy volunteers and to characterize the single-dose PK of...
Sponsor: Alnylam PharmaceuticalsEnrolling: 1442 locations
Obese or Overweight Healthy VolunteersType 2 Diabetes Mellitus (T2DM)
RECRUITINGPhase 3NCT07223203
TRITON-PN: A Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Hereditary Transthyretin...
The purpose of this study is to: * Determine the efficacy of nucresiran in patients with hATTR-PN by evaluating the effect on neurologic impairment, quality of life, nutritional...
Sponsor: Alnylam PharmaceuticalsEnrolling: 1251 location
Hereditary Transthyretin-Mediated Amyloidosis With PolyneuropathyhATTR-PN