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RECRUITINGOBSERVATIONAL

The Rogosin Institute Homozygous Familial Hypercholesterolemia Repository

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This repository will establish for the first time a system to carefully assess and monitor over time the general health and the amount of cholesterol in the arteries of U.S. children and adults with homozygous familial hypercholesterolemia (hoFH). Patients with this very rare disorder have very high blood levels of cholesterol from birth due to the inheritance of an abnormal gene from each parent. As a result, if untreated, heart attacks and sudden death occur in childhood. Treatments such as LDL-apheresis and liver transplant will lower the cholesterol level, but the best treatment and the best way to monitor the effect of the treatment on the arteries are unknown. The collection of clinical data and blood for analysis of known and yet-to-be discovered markers and predictors of arterial disease will yield new information about the natural history of the disorder and response to treatment. The repository will greatly aid the development of specific protocols that seek to learn more about this disease and new therapies.

Who May Be Eligible (Plain English)

Who May Qualify: 1\. Patients of any age and sex who meet clinical or genetic criteria for hoFH as follows: - Documented, untreated fasting LDL cholesterol level of \> 500 mg/dL and triglycerides \< 200 mg/dL on a cholesterol-lowering diet for at least 8 weeks with secondary causes excluded, AND: - DNA confirmation of a double mutation of the LDL receptor or apoB gene OR - LDL \> 160 mg/dL in both biological parents not associated with a disorder know to elevate LDL OR - Coronary artery disease in one or both parents or grandparents \< 55 years for males, \< 65 for females OR - Tendinous/cutaneous xanthomas \< age 10 or coronary artery disease \< age 20 Who Should NOT Join This Trial: 1\. Inability of patient, or, if less than 18, a parent, to sign willing to sign a consent form. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion criteria: 1\. Patients of any age and sex who meet clinical or genetic criteria for hoFH as follows: * Documented, untreated fasting LDL cholesterol level of \> 500 mg/dL and triglycerides \< 200 mg/dL on a cholesterol-lowering diet for at least 8 weeks with secondary causes excluded, AND: * DNA confirmation of a double mutation of the LDL receptor or apoB gene OR * LDL \> 160 mg/dL in both biological parents not associated with a disorder know to elevate LDL OR * Coronary artery disease in one or both parents or grandparents \< 55 years for males, \< 65 for females OR * Tendinous/cutaneous xanthomas \< age 10 or coronary artery disease \< age 20 Exclusion criteria: 1\. Inability of patient, or, if less than 18, a parent, to sign informed consent.

Locations (1)

Weill Cornell Medical College
New York, New York, United States