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RECRUITINGOBSERVATIONAL

Genes and Environment in Multiple Sclerosis

Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The purpose of the research study is to identify the genetic, environmental and immune profiles that may increase a person's risk of developing multiple sclerosis (MS). While MS is not a disease caused by a single variation in genetic material (DNA), a single environmental factor, or a single malfunction in immune cells, there are genetic alterations, environmental exposures and immunologic factors that make the development of MS more likely. Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease.

Who May Be Eligible (Plain English)

Who May Qualify: - First Degree Relatives of Patients with MS, or - Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or - Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS - Live in the United States Who Should NOT Join This Trial: - Does not match any of the inclusion criteria Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * First Degree Relatives of Patients with MS, or * Patients who have received anti-TNFa therapy as treatment for inflammatory diseases other than MS such as Crohn's disease, psoriasis and rheumatoid arthritis, or * Patients that have been referred for an evaluation of first presentation of neurologic symptoms but do not have a diagnosis of MS * Live in the United States Exclusion Criteria: * Does not match any of the inclusion criteria

Locations (5)

National Institute of Neurological Disorders and Stroke
Bethesda, Maryland, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Columbia University Irving Center
New York, New York, United States
University of Pittsburgh
Pittsburgh, Pennsylvania, United States