Neoadjuvant Radiosurgery for Resectable Brain Metastases: Phase I/II Study

Who May Qualify: - Have a prior histologic diagnosis of cancer other than small cell lung cancer, lymphoma, and germ cell histologies - Magnetic resonance imaging (MRI) evidence of 1-4 brain metastases, with at least one lesion \> 20 mm and ≤ 50 mm in maximal diameter and determined to be appropriate for SRS and gross total resection; all other brain metastases are appropriate for SRS - Patient can have prior SRS to lesions other than the one planned for neoadjuvant SRS and resection - Patient must have a Karnofsky performance score of ≥ 70 Who Should NOT Join This Trial: - Patient deemed medically unfit to undergo surgical resection of brain metastasis - Prior whole brain radiotherapy - Patient with contraindication for imaging with MRI - Inability to participate in study activities due to physical or mental limitations - Inability or unwillingness to return for all the required follow-up visits - At the time of planning, unable to deliver 10 Gray (Gy) or less to optic nerve/chiasm - Tumor located in the brainstem - Imaging or cytologic evidence of leptomeningeal disease Always talk to your doctor about whether this trial is right for you.