RECRUITINGINTERVENTIONAL
Improving Radical Treatment Through MRI Evaluation of Pelvic Sigmoid Cancers
About This Trial
Patients with suspected or proven sigmoid colon adenocarcinoma, eligible for curative treatment whose MRI can be reviewed prior to surgery and has no decision regarding radical treatment are eligible. Patient are randomised to the control arm which the standard care of preoperative CT imaging and subsequent discussion by the Multidisciplinary Team or the interventional arm which has the additional use of MRI imaging and subsequent discussion by the Multidisciplinary Team. Patients are followed up at 1 and 3 years together with QoL questionnaires.
Who May Be Eligible (Plain English)
Who May Qualify:
1. Have a suspected or proven sigmoid colon adenocarcinoma
2. Is eligible for curative treatment
3. Has no irresectable metastatic disease
4. MRI can be reviewed by an MDT prior to surgery
5. Has no decision regarding radical treatment
6. Have provided written willing to sign a consent form to participate in the study
7. Be aged 16 years or over
Who Should NOT Join This Trial:
1. Have metastatic disease (including resectable liver metastases)
2. Have a synchronous second malignancy
3. Are contraindicated for MRI
4. Are contraindicated for or have allergy to Buscopan (e.g. glaucoma, small or large bowel obstruction, GFR\<30)
5. Have severe co-morbidities or previous medical history that prevent the application of eventual chemo/radiotherapy
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
1. Have a suspected or proven sigmoid colon adenocarcinoma
2. Is eligible for curative treatment
3. Has no irresectable metastatic disease
4. MRI can be reviewed by an MDT prior to surgery
5. Has no decision regarding radical treatment
6. Have provided written informed consent to participate in the study
7. Be aged 16 years or over
Exclusion Criteria:
1. Have metastatic disease (including resectable liver metastases)
2. Have a synchronous second malignancy
3. Are contraindicated for MRI
4. Are contraindicated for or have allergy to Buscopan (e.g. glaucoma, small or large bowel obstruction, GFR\<30)
5. Have severe co-morbidities or previous medical history that prevent the application of eventual chemo/radiotherapy
Treatments Being Tested
OTHER
Preoperative MRI scan
Standard preoperative CT of abdomen, chest and pelvis plus interventional preoperative MRI scan.
Locations (16)
Hinchingbrooke Hospital
Huntingdon, Cambridgeshire, United Kingdom
Leighton Hospital
Crewe, Cheshire, United Kingdom
University Hospital of North Tees
Stockton-on-Tees, County Durham, United Kingdom
Croydon University Hospital
Thornton Heath, Croydon, United Kingdom
Chesterfield Royal
Chesterfield, Derbyshire, United Kingdom
Queen Alexandra Hospital
Portsmouth, Hampshire, United Kingdom
St Mark's Hospital
Middlesex, Harrow, United Kingdom
Maidstone Hospital
Maidstone, Kent, United Kingdom
Queen Elizabeth the Queen Mother Hospital
Margate, Kent, United Kingdom
North Manchester General Hospital
Crumpsall, Manchester, United Kingdom
University Hospital of South Manchester & Manchester Royal Infirmary
Wythenshawe, Manchester, United Kingdom
Harrogate District Hospital
Harrogate, North Yorkshire, United Kingdom
Musgrove Park Hospital
Taunton, Somerset, United Kingdom
Yeovil District Hospital
Yeovil, Somerset, United Kingdom
Royal Marsden Hospital
Sutton, Surrey, United Kingdom
Salisbury District Hospital
Salisbury, Whiltshire, United Kingdom