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RECRUITINGINTERVENTIONAL

Neuronal Effects of Exercise in Schizophrenia

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study plans to learn more about how common drugs prescribed to individuals with schizophrenia contribute to weight gain, as well as how exercise and diet impact appetite and the brain's response to food. In this study, the investigators will be evaluating how participants' brains respond to food images as well as asking questions about their food preferences and intake and clinical symptoms. The investigators may also ask participants to complete an exercise or diet intervention to see how this changes brain responses or food preferences.

Who May Be Eligible (Plain English)

Who May Qualify: - Diagnosis of schizophrenia or schizoaffective disorder - Between 21 and 70 years of age - Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, OR not currently being treated with any neuroleptic medications - Weight stable within 5 percent for the last 6 months Who Should NOT Join This Trial: - Pregnancy - Substance abuse - Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severe hypertriglyceridemia) - MRI-specific exclusion criteria (e.g., claustrophobia, metal in the body) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Diagnosis of schizophrenia or schizoaffective disorder * Between 21 and 70 years of age * Currently prescribed either olanzapine, risperidone, clozapine, or haloperidol, OR not currently being treated with any neuroleptic medications * Weight stable within 5 percent for the last 6 months Exclusion Criteria: * Pregnancy * Substance abuse * Significant endocrine/metabolic disease (e.g., uncontrolled hypertension, severe hypertriglyceridemia) * MRI-specific exclusion criteria (e.g., claustrophobia, metal in the body)

Treatments Being Tested

BEHAVIORAL

Exercise

BEHAVIORAL

Diet

Locations (1)

University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States