RECRUITINGOBSERVATIONAL
Prospective Research Rare Kidney Stones (ProRKS)
About This Trial
The purpose of this study is to determine the natural history of the hereditary forms of nephrolithiasis and chronic kidney disease (CKD), primary hyperoxaluria (PH), cystinuria, Dent disease and adenine phosphoribosyltransferase deficiency (APRTd) and acquired enteric hyperoxaluria (EH). The investigator will measure blood and urinary markers of inflammation and determine relationship to the disease course. Cross-comparisons among the disorders will allow us to better evaluate mechanisms of renal dysfunction in these disorders.
Who May Be Eligible (Plain English)
Who May Qualify:
1. Diagnosis of primary hyperoxaluria
2. Diagnosis of enteric hyperoxaluria
3. Diagnosis of Dent Disease
4. Diagnosis of Cystinuria
5. Diagnosis of adenine phosphoribosyltransferase deficiency (APRTd)
6. Diagnosis of Lowe Syndrome
7. Diagnosis of Dent Disease Carrier
Who Should NOT Join This Trial:
1. Prior renal failure
2. History of liver and/or kidney transplant.
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
1. Diagnosis of primary hyperoxaluria
2. Diagnosis of enteric hyperoxaluria
3. Diagnosis of Dent Disease
4. Diagnosis of Cystinuria
5. Diagnosis of adenine phosphoribosyltransferase deficiency (APRTd)
6. Diagnosis of Lowe Syndrome
7. Diagnosis of Dent Disease Carrier
Exclusion Criteria:
1. Prior renal failure
2. History of liver and/or kidney transplant.
Locations (11)
University of Alabama @ Birmingham
Birmingham, Alabama, United States
Mayo Clinic Jacksonville
Jacksonville, Florida, United States
Children's Memorial Hospital
Chicago, Illinois, United States
Children's Hospital, Harvard Medical School
Boston, Massachusetts, United States
Mayo Clinic Hyperoxaluria Center
Rochester, Minnesota, United States
New York University
New York, New York, United States
Cincinnati Children's Hosptial Medical Center
Cincinnati, Ohio, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Hosptial of Sick Children
Toronto, Ontario, Canada
Landspitali Universtiy Hospital
Reykjavik, Iceland
Shaare Zedek Medica Center
Jerusalem, Israel