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RECRUITINGOBSERVATIONAL

Heart Failure and Aortic Stenosis Transcriptome

Study of the Transcriptomic Alterations in Heart Failure and Aortic Stenosis

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study is aimed to investigate the global transcriptome in order to determine the expression profile of messenger RNAs (mRNAs), as well as long noncoding- (lncRNAs) and micro noncoding-RNAs (miRNAs) in heart failure (HF) and in aortic stenosis (AS). The aim is to clarify their role in cardiac disease pathogenesis, as well as their potential as biomarkers. To this purpose, both tissue and blood specimens will be collected and patients will be compared to individuals not affected by cardiovascular diseases.

Who May Be Eligible (Plain English)

Who May Qualify: 1. Non end-stage heart failure - left ventricle restoration surgery (SVR) - End Systolic Volume Index (ESVI) \>35 ml/m2 - Ejection Fraction (EF)\<40% - previous transmural anterior myocardial infarction (MI) - age: 40-75 2. End-stage heart failure - left ventricle assisted device (LVAD) surgery - age: 40-75 - Ejection Fraction (EF) \<25% - End Systolic Volume Index (ESVI)≥60 ml/m2 3. Aortic Stenosis - aortic valve replacement - intracardial pressure difference \>40 mmHg - septal diameter ≥1.3 cm Who Should NOT Join This Trial: 1. Non end-stage heart failure - End Systolic Volume Index (ESVI)\<35 ml/m2 - Ejection Fraction (EF)\>40% - Time from MI unknown - Pregnancy - Other genetic diseases - Neoplasms - Collagenopathies - Chemo/radiotherapy - Prolonged use of corticosteroids - Infections - Human weakened immune system Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive 2. End-stage heart failure - EF\>25% - Time from MI unknown - Pregnancy - Other genetic diseases - Neoplasms - Collagenopathies - Chemo/radiotherapy - Prolonged use of corticosteroids - Infections - Human weakened immune system Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive 3. Aortic Stenosis - coronaropathies - Pregnancy - Other genetic diseases - Neoplasms - Collagenopathies - Chemo/radiotherapy - Prolonged use of corticosteroids - Infections - Human weakened immune system Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Non end-stage heart failure * left ventricle restoration surgery (SVR) * End Systolic Volume Index (ESVI) \>35 ml/m2 * Ejection Fraction (EF)\<40% * previous transmural anterior myocardial infarction (MI) * age: 40-75 2. End-stage heart failure * left ventricle assisted device (LVAD) surgery * age: 40-75 * Ejection Fraction (EF) \<25% * End Systolic Volume Index (ESVI)≥60 ml/m2 3. Aortic Stenosis * aortic valve replacement * intracardial pressure difference \>40 mmHg * septal diameter ≥1.3 cm Exclusion Criteria: 1. Non end-stage heart failure * End Systolic Volume Index (ESVI)\<35 ml/m2 * Ejection Fraction (EF)\>40% * Time from MI unknown * Pregnancy * Other genetic diseases * Neoplasms * Collagenopathies * Chemo/radiotherapy * Prolonged use of corticosteroids * Infections * Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive 2. End-stage heart failure * EF\>25% * Time from MI unknown * Pregnancy * Other genetic diseases * Neoplasms * Collagenopathies * Chemo/radiotherapy * Prolonged use of corticosteroids * Infections * Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive 3. Aortic Stenosis * coronaropathies * Pregnancy * Other genetic diseases * Neoplasms * Collagenopathies * Chemo/radiotherapy * Prolonged use of corticosteroids * Infections * Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV) (not vaccination) and Hepatitis C Virus (HCV) positive

Treatments Being Tested

DIAGNOSTIC_TEST

measurement of RNAs

Locations (2)

Irccs Policlinico San Donato
San Donato Milanese, Milan, Italy
Ospedale San Raffaele
Milan, Italy