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RECRUITINGINTERVENTIONAL

The Effects of Different Anesthetics on Functional Connectivity

The Effects of Different Anesthetics on Functional Connectivity in Volunteers and Patients With Brain Tumor (ACTION)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This research is a prospective cohort study. The aim of the study is to determine different levels of sedative mechanism and the effect on brain functional connectivity of midazolam, dexmedetomidine and propofol.

Who May Be Eligible (Plain English)

Who May Qualify: - 1\. Male, 18 \~ 65 years old - 2\. Healthy Volunteer / Brain Tumor Patients - 3\. Senior high school and above - 4\. Sign willing to sign a consent form Who Should NOT Join This Trial: - 1\. In vivo implant MRI check taboo - 2\. Cardiopulmonary liver and kidney and other systemic complications - 3\. History of major surgical anesthesia - 4\. Abuse of drugs, alcoholism history - 5\. Test drug allergy history - 6\. Claustrophobia - 7\. Left hand Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * 1\. Male, 18 \~ 65 years old * 2\. Healthy Volunteer / Brain Tumor Patients * 3\. Senior high school and above * 4\. Sign informed consent Exclusion Criteria: * 1\. In vivo implant MRI check taboo * 2\. Cardiopulmonary liver and kidney and other systemic complications * 3\. History of major surgical anesthesia * 4\. Abuse of drugs, alcoholism history * 5\. Test drug allergy history * 6\. Claustrophobia * 7\. Left hand

Treatments Being Tested

DRUG

Midazolam

Midazolam was administered intravenously at a dose of 0.1 mg / kg followed by continuous intravenous injection at 0.03 mg / kg / h and maintained until the course of the scan.

DRUG

Propofol

Propofol group 1mg / kg intravenous injection, followed by 2mg / kg / h continuous intravenous injection, and maintained to the scanning process;

DRUG

Dexmedetomidine

Dexmedetomidine group with total amount of 1μg / kg, infusion time 15min, followed by 0.6μg / kg / h, and maintained to the scanning process;

Locations (1)

Beijing Tian Tan Hospital
Beijing, China