PET Imaging CCR2 in Lung Inflammation

Who May Qualify: - Men or women 21 years of age or older who have never smoked or current smokers who smoked at least 10 cigarettes per day (1/2 pack) and have smoked at least 100 cigarettes (5 packs) over the past month. - Screening FEV1 and FVC \> 80% of predicted - Capable of lying still and supine within the PET/CT and PET/MR scanner for \~1 hour and follow instructions for breathing protocol during the CT portion - No illicit drug use or other inhaled drug use (including pharmacologic agents, recreational agents, or illicit drugs) within the past year - No known history of cardiac, pulmonary, hepatic or renal disease or diabetes - No history of claustrophobia or other preventing condition that has previously or would interfere with completion of protocol specified imaging sessions - Able to comprehend and willing to follow instructions for the study procedures as called for by the protocol - BMI ≤ 35 Who Should NOT Join This Trial: - Currently enrolled in another study using an investigational drug - Pregnancy (confirmed by urine pregnancy test) - Active symptoms or history of cardiac, pulmonary, hepatic or renal disease or diabetes - Currently taking any prescription medications - Presence of an implanted device that is incompatible with CT or MRI scanning - Creatinine \> 1.30 mg/dL, AST \> 50 Units/L, ALT \> 55 Units/L, or total bilirubin \> 1.2 mg/dL Always talk to your doctor about whether this trial is right for you.