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RECRUITINGINTERVENTIONAL

Intracameral Versus Intravitreal Bevacizumab Injection in NVG: RCT

Efficacy and Safety of Intracameral Versus Intravitreal Bevacizumab Injection as an Adjunctive Therapy Before Trabeculectomy With Mitomycin-C in Neovascular Glaucoma: A Prospective Randomized Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

To prospect studying the efficacy and safety of treating NVG with the intracameral versus the intravitreal injection of Bevacizumab.

Who May Be Eligible (Plain English)

Who May Qualify: 1. Diagnosis of neovascular glaucoma 2. The patients having IOP \> 21 mmHg, having the indication for trabeculectomy 3. The patients' age of at least 18-year-old 4. The patients having visual potential at least hand motion. 5. Present of NVI or NVA. 6. Willing and able to provide willing to sign a consent form to participate in the study 7. Able to understand the purpose of the study, his/her role, and is available to return to the clinic/hospital for all required follow-up visits Who Should NOT Join This Trial: 1. One eye patient 2. Patients having severe corneal edema or total hyphema obscure NVI or NVA view. 3. Cannot obtain endothelial cell count. 4. History of bevacizumab or fluorescence dye allergy. 5. Active infectious ocular disease including endophthalmitis and corneal ulcer 6. History of systemic disease including ischemic heart disease, cerebrovascular disease, end-stage renal disease, liver failure, uncontrolled hypertension 7. Has or planning to be pregnant or breastfeeding Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Diagnosis of neovascular glaucoma 2. The patients having IOP \> 21 mmHg, having the indication for trabeculectomy 3. The patients' age of at least 18-year-old 4. The patients having visual potential at least hand motion. 5. Present of NVI or NVA. 6. Willing and able to provide informed consent to participate in the study 7. Able to understand the purpose of the study, his/her role, and is available to return to the clinic/hospital for all required follow-up visits Exclusion Criteria: 1. One eye patient 2. Patients having severe corneal edema or total hyphema obscure NVI or NVA view. 3. Cannot obtain endothelial cell count. 4. History of bevacizumab or fluorescence dye allergy. 5. Active infectious ocular disease including endophthalmitis and corneal ulcer 6. History of systemic disease including ischemic heart disease, cerebrovascular disease, end-stage renal disease, liver failure, uncontrolled hypertension 7. Has or planning to be pregnant or breastfeeding

Treatments Being Tested

PROCEDURE

Intracameral injection

A/C injection of 1.25 mg/0.05 mL bevacizumab

PROCEDURE

Intravitreal injection

Vitreous injection of 1.25 mg/0.05 mL bevacizumab

Locations (1)

Glaucoma unit , Department of Ophthalmology Faculty of Medicine Prince of Songkla University
Hat Yai, Changwat Songkhla, Thailand