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RECRUITINGINTERVENTIONAL

Caffeine Consumption in Glaucoma Patients and Healthy Subjects

Acute Changes in Optic Nerve Head (ONH) and Macular Blood Flow After Caffeine Consumption in Glaucoma Patients and Healthy Subjects: A Quantitative Optic Coherence Tomography Angiography (OCTA) Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Caffeine is the most widely consumed drinking nutrient in the world. Caffeine effects various organs and the vascular system. It decreases ocular blood flow due to vasoconstriction.

Who May Be Eligible (Plain English)

Who May Qualify: - age 18 to 90 years - diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced) - healthy subjects with no eye disease Who Should NOT Join This Trial: - Diseases, ophthalmic or systemic, that are likely to affect OCTA results - greater than moderate cataract - nystagmus - inability to look at target - macular degeneration other than mild drusen or pigmentary changes - diabetic retinopathy - neovascular glaucoma or non-glaucoma optic neuropathies - current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy - keratoconus, corneal ectasia, central corneal scarring - rheumatologic diseases or Raynaud's phenomena - pregnant and lactating women - mental illness or alcohol addiction - pre-existing bladder symptoms, cardiac disease or sleep disorder - refractive spherical diopter greater than 5 or cylinder greater than 3 - possible tolerance to caffeine (drinking more than 1 cup coffee per day). Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * age 18 to 90 years * diagnosis of primary open angle glaucoma (Mild, Moderate and Advanced) * healthy subjects with no eye disease Exclusion Criteria: * Diseases, ophthalmic or systemic, that are likely to affect OCTA results * greater than moderate cataract * nystagmus * inability to look at target * macular degeneration other than mild drusen or pigmentary changes * diabetic retinopathy * neovascular glaucoma or non-glaucoma optic neuropathies * current macular edema, prior laser to retina, inflammatory retinopathy or choroidopathy * keratoconus, corneal ectasia, central corneal scarring * rheumatologic diseases or Raynaud's phenomena * pregnant and lactating women * mental illness or alcohol addiction * pre-existing bladder symptoms, cardiac disease or sleep disorder * refractive spherical diopter greater than 5 or cylinder greater than 3 * possible tolerance to caffeine (drinking more than 1 cup coffee per day).

Treatments Being Tested

DIETARY_SUPPLEMENT

Caffeine tablet

Each eligible participant will receive one 200 mg caffeine tablet to ingest after completing all baseline study tasks.

Locations (1)

Wills Eye Glaucoma Service
Philadelphia, Pennsylvania, United States