RECRUITINGINTERVENTIONAL
Sleep-dependent Learning in Aging
What is Sleep's Role in Alzheimer's Disease? Insight From Healthy Aging
About This Trial
The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.
Who May Be Eligible (Plain English)
Who May Qualify:
- Age 18-80 yrs
- Healthy sleeper
- No diagnosed sleep or neurodegenerative disorder
Who Should NOT Join This Trial:
1. Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index \>15; a Period-Limb Movement in Sleep index of \>15/hr; sleep-onset latency \> 45 min (indicative of insomnia); or sleep efficiency \< 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation.
2. Past diagnosis neurological illness or head injury
3. Reported average sleep per night \< 5 or \> 9 hrs
4. Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing
5. Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)
6. Daily caffeine intake of \> 4 cups (coffee, tea, colas)
7. Weekly alcohol intake of \> 10 cups
8. Pregnancy or \< 12 months post-partum
9. History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score \> 25
10. Abnormal sleep (e.g., shift work, travel across \>2 time zones within the past 3 months).
11. Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form);
12. Score indicative of cognitive dysfunction (subtest scores \< 40)
13. Beck Depression Scale score indicative of depression (\> 19).
Additionally, individuals will be excluded from magnetic resonance imaging studies (Exps 1, 4) for:
1. Left handed or ambidextrous
2. Claustrophobia
...See full criteria on ClinicalTrials.gov
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Age 18-80 yrs
* Healthy sleeper
* No diagnosed sleep or neurodegenerative disorder
Exclusion Criteria:
1. Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index \>15; a Period-Limb Movement in Sleep index of \>15/hr; sleep-onset latency \> 45 min (indicative of insomnia); or sleep efficiency \< 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation.
2. Past diagnosis neurological illness or head injury
3. Reported average sleep per night \< 5 or \> 9 hrs
4. Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing
5. Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)
6. Daily caffeine intake of \> 4 cups (coffee, tea, colas)
7. Weekly alcohol intake of \> 10 cups
8. Pregnancy or \< 12 months post-partum
9. History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score \> 25
10. Abnormal sleep (e.g., shift work, travel across \>2 time zones within the past 3 months).
11. Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form);
12. Score indicative of cognitive dysfunction (subtest scores \< 40)
13. Beck Depression Scale score indicative of depression (\> 19).
Additionally, individuals will be excluded from magnetic resonance imaging studies (Exps 1, 4) for:
1. Left handed or ambidextrous
2. Claustrophobia
3. Presence of metal (thoroughly screened via questionnaire and metal detector)
4. Pregnancy
Treatments Being Tested
BEHAVIORAL
Sleep
Participants will sleep (either a mid-day nap or normal overnight sleep)
Locations (1)
University of Massachusetts
Amherst, Massachusetts, United States