The Registry Study of Takayasu Arteritis in East China

Inclusion Criteria - onset at age ≤40 years; - claudication of an extremity; - decreased brachial artery pulse; - \>10 mm Hg difference in systolic blood pressure between arms; - a bruit over the subclavian arteries or the aorta; - angiographic evidence of narrowing or occlusion of the entire aorta, its primary branches, or large arteries in the proximal upper or lower extremities. - Patients should meet at least 3 of the above 6 articles. - Sign the willing to sign a consent form Exclusion Criteria - autoimmune conditions (where your immune system attacks your own body)s, such as ANCA-associated vasculitis, systemic lupus erythematosus, Behcet's disease, rheumatoid arthritis, ankylosing spondylitis, etc.; - complicated medical abnormal conditions, un-related with TA but engendering the unpredictable risks, such as severe, progressive, or uncontrollable kidney, liver, blood, gastrointestinal, pulmonary, heart, neuron or others - malignant tumors; - serious acute or chronic infections; - high risk of tuberculosis infection such as clinical, radiological or laboratory evidence of active or occult tuberculosis, or the history of active tuberculosis; - Having received or plan to receive plasma exchange or lymphocyte replacement or immunoabsorption therapy within 1 year. - Preparing to receive an attenuated vaccine during the trial; - Having received or plan to receive an organ transplant; Exit criteria - participants require to withdraw during the study; - participants who believe that they need to withdraw due to clinical adverse events; - Participants can not or does not comply with the requirements of the research protocol; Always talk to your doctor about whether this trial is right for you.