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RECRUITINGPhase 4INTERVENTIONAL

Advanced Therapeutics in Rheumatoid Arthritis (RA)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study will evaluate the retention rates of two advanced therapies, Tumour Necrosis Factor (TNF) and Janus kinase inhibitor (JAK) in the treatment of adults with Rheumatoid Arthritis (RA) over a two year period. It will also examine the ability to embed a clinical trial in a clinical situation using an electronic medical record (EMR).

Who May Be Eligible (Plain English)

Who May Qualify: - patients with RA who meet criteria for obtaining an advanced therapeutic through usual care - active RA with 5 or more swollen joints - seropositive - presence of erosions - failure of methotrexate and hydroxychloroquine and sulfasalazine - failure of Leflunomide -\> or equal to 18 years - able to provide consent - able to attend usual follow up visits Who Should NOT Join This Trial: - no contraindication to etanercept or tofacitinib - active serious infection - active Tuberculosis - multiple sclerosis - current cancer - lymphoma ever - previous use of an advanced therapeutic (biologic or JAK kinase inhibitor) - less than 18 years of age - unable to provide consent Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * patients with RA who meet criteria for obtaining an advanced therapeutic through usual care * active RA with 5 or more swollen joints * seropositive * presence of erosions * failure of methotrexate and hydroxychloroquine and sulfasalazine * failure of Leflunomide -\> or equal to 18 years * able to provide consent * able to attend usual follow up visits Exclusion Criteria: * no contraindication to etanercept or tofacitinib * active serious infection * active Tuberculosis * multiple sclerosis * current cancer * lymphoma ever * previous use of an advanced therapeutic (biologic or JAK kinase inhibitor) * less than 18 years of age * unable to provide consent

Treatments Being Tested

DRUG

Etanercept

injection

DRUG

tofacitinib

tablet

Locations (1)

Rheumatology Clinic, St. Joseph's Health Care
London, Ontario, Canada