Phenotypes, Biomarkers and Pathophysiology in Hereditary Spastic Paraplegias and Related Disorders

Who May Qualify: - One of the following: 1. Primary participant: Clinical or genetic diagnosis of HSP or a related disorder 2. Secondary participant: Unaffected family member (1st or 2nd degree relative) of primary participant (with the above-mentioned restrictions for special populations) able to give willing to sign a consent form 3. Unrelated healthy control able to give willing to sign a consent form AND - Written willing to sign a consent form AND \- Participants are willing and able to comply with study procedures Who Should NOT Join This Trial: - Missing willing to sign a consent form of primary or secondary participant/ healthy control/ legal representatives - For controls: evidence of a neurodegenerative disease or movement disorders; inability to give willing to sign a consent form Always talk to your doctor about whether this trial is right for you.