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RECRUITINGOBSERVATIONAL

DBS and Respiration

Deep Brain Stimulation in Parkinson's Disease: Respiratory Testing

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of neurological conditions, most commonly Parkinson's disease. The investigators have observed that respiratory problems (breathlessness) sometimes occur subsequent to DBS of the subthalamic nucleus (STN). This study aims to determine whether this is indeed a consequence of STN stimulation. Secondary objectives include identification of the respiratory physiological mediators of any interoceptive neuromodulation observed, changes in daily physical activity and MRI structural connectivity analysis.

Who May Be Eligible (Plain English)

Who May Qualify: - Participant is willing and able to give willing to sign a consent form for participation in the study. - Male or female, aged 18 years or above. - Planned for required DBS surgery - Fluent in the English language - For experimental group: diagnosed with Parkinson's disease Who Should NOT Join This Trial: - Female who is pregnant - Subject is currently participating in a clinical investigation that includes an active treatment arm which may affect the respiratory system. - Acute respiratory problem at time of experimental session: e.g. rhinosinusitis, pharyngitis, asthma exacerbation Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male or female, aged 18 years or above. * Planned for required DBS surgery * Fluent in the English language * For experimental group: diagnosed with Parkinson's disease Exclusion Criteria: * Female who is pregnant * Subject is currently participating in a clinical investigation that includes an active treatment arm which may affect the respiratory system. * Acute respiratory problem at time of experimental session: e.g. rhinosinusitis, pharyngitis, asthma exacerbation

Treatments Being Tested

DEVICE

DBS

Patients are tested pre-operatively and the post-operatively with their implanted neurostimulators ON and OFF. DBS implantation itself is part of routine care, and not part of the study.

Locations (1)

John Radcliffe Hospital
Oxford, Oxfordshire, United Kingdom