RECRUITINGOBSERVATIONAL
Registry of Subjects at Risk of Pancreatic Cancer
Italian Registry of Families At Risk of Pancreatic Cancer
About This Trial
IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.
Who May Be Eligible (Plain English)
Inclusion Criteria to enter the registry:
- individuals with at least two relatives suffering from pancreatic cancer, with at least 1 first-degree and until the third-degree
- subjects with known genetic mutation of BRCA2, BRCA1, p16, PALB2 with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
- subjects suffering from FAMMM Syndrome
- subjects suffering from Peutz-Jeghers Syndrome
- subjects suffering from PRSS-1- or CFTR- or SPINK-1- related pancreatitis
- subjects suffering from Lynch syndrome with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
Inclusion criteria to join the "radiologic follow-up":
- 45 years or 10 years younger than the youngest index case of pancreatic cancer in the family for familial cases
- 40 years or 5 years younger than the youngest index case of pancreatic cancer for subjects suffering from hereditary/genetic pancreatitis, Lynch syndrome, or carrying a known BRCA 1/2, PALB2, p16 genetic mutation with familiarity for pancreatic cancer
- 30 years for subjects suffering from FAMMM, Peutz-Jeghers syndrome
Who Should NOT Join This Trial:
\- pregnancy
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria to enter the registry:
* individuals with at least two relatives suffering from pancreatic cancer, with at least 1 first-degree and until the third-degree
* subjects with known genetic mutation of BRCA2, BRCA1, p16, PALB2 with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
* subjects suffering from FAMMM Syndrome
* subjects suffering from Peutz-Jeghers Syndrome
* subjects suffering from PRSS-1- or CFTR- or SPINK-1- related pancreatitis
* subjects suffering from Lynch syndrome with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer
Inclusion criteria to join the "radiologic follow-up":
* 45 years or 10 years younger than the youngest index case of pancreatic cancer in the family for familial cases
* 40 years or 5 years younger than the youngest index case of pancreatic cancer for subjects suffering from hereditary/genetic pancreatitis, Lynch syndrome, or carrying a known BRCA 1/2, PALB2, p16 genetic mutation with familiarity for pancreatic cancer
* 30 years for subjects suffering from FAMMM, Peutz-Jeghers syndrome
Exclusion Criteria:
\- pregnancy
Treatments Being Tested
RADIATION
MRCP
Subjects fulfilling the "radiological follow-up criteria" will be submitted to MRCP or EUS according to the pancreatologist's prescription
PROCEDURE
Endoultrasonography
Subjects fulfilling the "radiological follow-up criteria" will be submitted to MRCP or EUS according to the pancreatologist's prescription
Locations (4)
Istituto Clinico Humanitas
Rozzano, Milan, Italy
Ospedale Pederzoli
Peschiera del Garda, Verona, Italy
San Raffele Vita Salute University Hospital
Milan, Italy
Chirurgia Generale e del Pancreas
Verona, Italy