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RECRUITINGOBSERVATIONAL

Registry of Subjects at Risk of Pancreatic Cancer

Italian Registry of Families At Risk of Pancreatic Cancer

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

IRFARPC is a multicenter national registry designed to study the diagnosis and predisposing factors of subjects with an inherited increased risk for pancreatic cancer.

Who May Be Eligible (Plain English)

Inclusion Criteria to enter the registry: - individuals with at least two relatives suffering from pancreatic cancer, with at least 1 first-degree and until the third-degree - subjects with known genetic mutation of BRCA2, BRCA1, p16, PALB2 with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer - subjects suffering from FAMMM Syndrome - subjects suffering from Peutz-Jeghers Syndrome - subjects suffering from PRSS-1- or CFTR- or SPINK-1- related pancreatitis - subjects suffering from Lynch syndrome with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer Inclusion criteria to join the "radiologic follow-up": - 45 years or 10 years younger than the youngest index case of pancreatic cancer in the family for familial cases - 40 years or 5 years younger than the youngest index case of pancreatic cancer for subjects suffering from hereditary/genetic pancreatitis, Lynch syndrome, or carrying a known BRCA 1/2, PALB2, p16 genetic mutation with familiarity for pancreatic cancer - 30 years for subjects suffering from FAMMM, Peutz-Jeghers syndrome Who Should NOT Join This Trial: \- pregnancy Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria to enter the registry: * individuals with at least two relatives suffering from pancreatic cancer, with at least 1 first-degree and until the third-degree * subjects with known genetic mutation of BRCA2, BRCA1, p16, PALB2 with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer * subjects suffering from FAMMM Syndrome * subjects suffering from Peutz-Jeghers Syndrome * subjects suffering from PRSS-1- or CFTR- or SPINK-1- related pancreatitis * subjects suffering from Lynch syndrome with at least 1 first- or 2nd-degree relative suffering from pancreatic cancer Inclusion criteria to join the "radiologic follow-up": * 45 years or 10 years younger than the youngest index case of pancreatic cancer in the family for familial cases * 40 years or 5 years younger than the youngest index case of pancreatic cancer for subjects suffering from hereditary/genetic pancreatitis, Lynch syndrome, or carrying a known BRCA 1/2, PALB2, p16 genetic mutation with familiarity for pancreatic cancer * 30 years for subjects suffering from FAMMM, Peutz-Jeghers syndrome Exclusion Criteria: \- pregnancy

Treatments Being Tested

RADIATION

MRCP

Subjects fulfilling the "radiological follow-up criteria" will be submitted to MRCP or EUS according to the pancreatologist's prescription

PROCEDURE

Endoultrasonography

Subjects fulfilling the "radiological follow-up criteria" will be submitted to MRCP or EUS according to the pancreatologist's prescription

Locations (4)

Istituto Clinico Humanitas
Rozzano, Milan, Italy
Ospedale Pederzoli
Peschiera del Garda, Verona, Italy
San Raffele Vita Salute University Hospital
Milan, Italy
Chirurgia Generale e del Pancreas
Verona, Italy