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RECRUITINGOBSERVATIONAL

Comparative Imaging Assessment of Valvular Heart Disease

Assessment of Left Ventricular Volumes and Strain and Assessment of Valvular Lesions Using Two- and Three-dimensional Echocardiography and Cardiac MRI, a Correlation Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The purpose of the study is to compare the various 2D and 3D methods of valvular heart disease quantification (Doppler, PISA, VCA, volumetric method) and strain with cardiac magnetic resonance (CMR) measurements of left and right ventricular systolic function strain and myocardial fibrosis assessment.

Who May Be Eligible (Plain English)

Who May Qualify: - Age 18-90 years of age - Suspected moderate or severe MR,AR or AS on the basis of prior known clinical history or clinical exam. - Suspected CRT "non-responder" with an implanted MRI compatible CRT device and reduced ejection fraction Who Should NOT Join This Trial: - Acute traumatic cardiac injury - Aortic dissection or aortic root rupture - Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD - Presence of A-V fistula or intracardiac shunts - Any contraindications to CMR - Moderate or severe dysfunction in multiple valves - Patients with significant claustrophobia Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age 18-90 years of age * Suspected moderate or severe MR,AR or AS on the basis of prior known clinical history or clinical exam. * Suspected CRT "non-responder" with an implanted MRI compatible CRT device and reduced ejection fraction Exclusion Criteria: * Acute traumatic cardiac injury * Aortic dissection or aortic root rupture * Congenital heart diseases such as patent ductus arteriosus, coarctation of aorta, ASD and VSD * Presence of A-V fistula or intracardiac shunts * Any contraindications to CMR * Moderate or severe dysfunction in multiple valves * Patients with significant claustrophobia

Treatments Being Tested

DIAGNOSTIC_TEST

MRI with strain measurement

CMR measurements of left and right ventricular systolic function strain and myocardial fibrosis

DIAGNOSTIC_TEST

Echocardiography

Doppler, PISA, VCA, volumetric method as performed during echocardiography

Locations (1)

Cleveland Clinic
Cleveland, Ohio, United States