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RECRUITINGOBSERVATIONAL

Autonomic Small Fiber Neuropathy and Ehlers Danlos Syndromes - Prospective Study and Registry

Autonomic Neuropathy and Its Pathophysiology in Autoimmune Autonomic Neuropathies, Postural Orthostatic Tachycardia Syndrome and Ehlers Danlos Syndromes: Peripheral Autonomic Small Fiber Neuropathy or Central Autonomic Failure? Validation of the Malmö POTS Score and a Better Diagnosis of POTS in Patientes With Autnomic Failure (VaGeMAPS-3-step-Diag)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

We examine patients with different autonomic neuropathies and Ehlers Danlos syndromes compared to healthy controls at three different points over time (baseline, after 3 months and after 1.5 years) to gain knowledge about the course of this disease and understand its pathophysiology, with a focus on Small Fiber neuropathy. Moreover we will validate the german version of the Malmö POTS Score and establish an easy diagnostic scheme for patients in outpatient care.

Who May Be Eligible (Plain English)

Who May Qualify: - autonomic neuropathy - Postural orthostatic tachycardia syndrome - hypermobile or classical Ehlers Danlos syndromes - Chronic fatigue syndrome, mast cell activation syndrome and/or PostCOVID - healty controls - between 18-80 years - in patients: diagnosis and clinical testing in our outpatient clinic - German speaking Who Should NOT Join This Trial: - pregnancy - Pacemaker or Deep brain Stimulation - sensory or motor Polyneuropathy - neurodegenerative disease Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * autonomic neuropathy * Postural orthostatic tachycardia syndrome * hypermobile or classical Ehlers Danlos syndromes * Chronic fatigue syndrome, mast cell activation syndrome and/or PostCOVID * healty controls * between 18-80 years * in patients: diagnosis and clinical testing in our outpatient clinic * German speaking Exclusion Criteria: * pregnancy * Pacemaker or Deep brain Stimulation * sensory or motor Polyneuropathy * neurodegenerative disease

Treatments Being Tested

OTHER

No intervention planned, but all patients get our standart treatment

Patients are selected from clinical Routine and get our standart Treatment based on their disease

Locations (1)

University clinic RWTH Aachen
Aachen, North Rhine-Westphalia, Germany