Combining MyoCI With Memory Reactivation to Improve Motor Recovery After Stroke

Who May Qualify: - Age at enrollment is 21 or older - Hemiparesis from first ever stroke affecting arm movement at least 6 months prior to screening - Severe to moderate motor impairment (FMA-UE of 7-40) - At least some voluntary shoulder and elbow muscle activation Who Should NOT Join This Trial: - Inability to follow instructions of the MyoCI task - Visual impairment (such as hemianopia) preventing full view of screen - Anesthesia or neglect in the affected arm, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest) - Participation in another study on the affected arm within 6 weeks of enrollment or any pharmacological study - Inability to understand or follow commands in English due to aphasia or other reason - Diffuse or multifocal infarcts in both hemispheres - Substantial arm pain preventing participation for 90 minutes a day - Spasticity treatment (pharmacological or Botox) within last 3 months - Ferromagnetic implants that are MRI incompatible Always talk to your doctor about whether this trial is right for you.