RECRUITINGOBSERVATIONAL
Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis
About This Trial
The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.
Who May Be Eligible (Plain English)
Who May Qualify:
- 18-50 years old
- BMI of 25 - 30 kg/m2
- BMI \> 40kg/m2
- Lactate levels in top and lower 25%
Who Should NOT Join This Trial:
- Pregnant women
- Mentally disabled
- Prisoners
- Smokers
- Subjects with heart disease
- Type 1 and 2 diabetes
- Endocrine disease
- Hypertension
- Musculoskeletal disease
- Peripheral occlusion
- Hepatic disease
- Have had weight fluctuations exceeding + 3% in the previous 12 months
- On medications which alter carbohydrate metabolism will not be studied
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* 18-50 years old
* BMI of 25 - 30 kg/m2
* BMI \> 40kg/m2
* Lactate levels in top and lower 25%
Exclusion Criteria:
* Pregnant women
* Mentally disabled
* Prisoners
* Smokers
* Subjects with heart disease
* Type 1 and 2 diabetes
* Endocrine disease
* Hypertension
* Musculoskeletal disease
* Peripheral occlusion
* Hepatic disease
* Have had weight fluctuations exceeding + 3% in the previous 12 months
* On medications which alter carbohydrate metabolism will not be studied
Treatments Being Tested
PROCEDURE
Weight loss surgery
Severely obese women (BMI \>40) undergo sleeve gastrectomy
Locations (1)
East Carolina University
Greenville, North Carolina, United States