Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study

Who May Qualify: - Adults age 18 or older - Prior allogeneic stem cell transplant, with any graft source, donor type, and GVHD prophylaxis - No evidence of persistent or progressive malignancy at the time of enrollment - Agrees to be evaluated at the transplant center before a new line of treatment is started (may be concurrent with the enrollment visit), and later between 2-6 weeks, 3 months and 6 months after index treatment is started or if an additional new therapy is started before 6 months - Signed, willing to sign a consent form Who Should NOT Join This Trial: - Inability to comply with study procedures - Uncontrolled psychiatric disorder - Anticipated survival \< 6 months Always talk to your doctor about whether this trial is right for you.