Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC

Who May Qualify: - ≥ 18 years of age - T0-T2 N2a-N3 M0 or T3-T4 N0-N3 M0 (AJCC 7th edition) - Biopsy proven squamous cell carcinoma of the oropharynx or unknown primary - No prior therapy - No evidence of distant metastatic disease - p16 positive = diffuse ≥ 70% tumor cell expression, with at least moderate (2/3+) staining intensity - Planned for receipt of definitive cancer treatment - You should be able to carry out daily activities with 0 level of ability (ECOG 0)-1 - Patients must be deemed able to comply with the treatment plan and follow-up schedule. - Patients must provide study specific willing to sign a consent form prior to study entry Who Should NOT Join This Trial: All subjects meeting any of the exclusion criteria at baseline will be excluded from study participation: - Prior history of radiation therapy to the head and neck - Prior history of head and neck cancer. - Inadequate pre-treatment tissue sample for tumor genomic analyses Always talk to your doctor about whether this trial is right for you.