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RECRUITINGOBSERVATIONAL

Excessive Supraventricular Activity and Atrial Fibrillation

Detection of Atrial Fibrillation in Patients With Excessive Supraventricular Activity

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of the proposed study is to determine if individuals with excessive supraventricular ectopic activity (ESVEA) on Holter recording should be subjected to prolonged screening with Event loop recorder in order to detect previously undiagnosed Atrial fibrillation / flutter. Other biomarkers such as plasma biomarkers, high-end echocardiography and assessment of blood pressure and atrial stiffness will be studied and compared in ESVEA and control group as well as progression of atrial cardiomyopathy in ESVEA patients.

Who May Be Eligible (Plain English)

Who May Qualify: Patients with at least 30 supraventricular extra systole (SVES)/h or a supraventricular run of at least 20 beats on a Holter recording. Who Should NOT Join This Trial: Age \< 70 years, \>89 years Atrial fibrillation / flutter Lifelong treatment with oral anticoagulant Patients with implantable cardiac device Congestive heart failure (CHF) with Ejection fraction (EF) ≤ 30% Severe valvular heart disease Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: Patients with at least 30 supraventricular extra systole (SVES)/h or a supraventricular run of at least 20 beats on a Holter recording. Exclusion Criteria: Age \< 70 years, \>89 years Atrial fibrillation / flutter Lifelong treatment with oral anticoagulant Patients with implantable cardiac device Congestive heart failure (CHF) with Ejection fraction (EF) ≤ 30% Severe valvular heart disease

Treatments Being Tested

DIAGNOSTIC_TEST

Holter recording

Holter recording with Zenicor Flex ECG during 14 days.

DIAGNOSTIC_TEST

Echocardiography (Echo)

Echocardiography: Comprehensive transthoracic echocardiography with special focus on atrial dimension and function.

DIAGNOSTIC_TEST

Blood sample

Blood sample: 2 x 10 ml EDTA plasma sampled from venous blood at index and at 21 months. Troponin T, NTproBNP, Na, K, Creatinine. Sample for Biobank for future analysis.

DIAGNOSTIC_TEST

24 hour ambulatory blood pressure monitoring And Arteriograph

To assess artery stiffness.

Locations (1)

Danderyd Hospital
Stockholm, Sweden