RECRUITINGOBSERVATIONAL
Pathogenesis of Pediatric Nonalcoholic Fatty Liver Disease (NAFLD)
Pathophysiologic Mechanisms Leading to Intrahepatic Fat Accumulation in Obese Youth
About This Trial
The main aim of the study is to discover the mechanisms underlying the pathophysiology of NAFLD in obese youth.
Who May Be Eligible (Plain English)
Who May Qualify:
- Good general health, taking no medication on a chronic basis;
- age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
- BMI \>85th for obese cohort;
Who Should NOT Join This Trial:
- Baseline creatinine \>1.0 mg; pregnancy;
- the presence of endocrinopathies (e.g. Cushing syndrome);
- cardiac or pulmonary or other significant chronic illness;
- adolescents with a psychiatric disorder or with substance abuse;
- monogenic obesity syndromes;
- use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Good general health, taking no medication on a chronic basis;
* age 12 to 18 years, in puberty (girls and boys: Tanner stage II-V);
* BMI \>85th for obese cohort;
Exclusion Criteria:
* Baseline creatinine \>1.0 mg; pregnancy;
* the presence of endocrinopathies (e.g. Cushing syndrome);
* cardiac or pulmonary or other significant chronic illness;
* adolescents with a psychiatric disorder or with substance abuse;
* monogenic obesity syndromes;
* use of drugs affecting intrahepatic fat content (e.g.; liraglutide, fish oil, etc.).
Treatments Being Tested
OTHER
Usual diet and physical activity
Patients will be followed up to assess the effect of the usual diet and physical activity on development of NAFLD
Locations (1)
Yale New Haven Hospital
New Haven, Connecticut, United States