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RECRUITINGEarly Phase 1INTERVENTIONAL

Localizing Epileptic Networks Using MRI and iEEG

Optimized Intracranial EEG Targeting in Focal Epilepsy Based Upon Neuroimaging Connectomics

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Upon successful completion of this study, the investigators expect the study's contribution to be the development of noninvasive imaging biomarkers to predict IEEG functional dynamics and epilepsy surgical outcomes. Findings from the present study may inform current and new therapies to map and alter seizure spread, and pave the way for less invasive, better- targeted, patient-specific interventions with improved surgical outcomes. This research is relevant to public health because over 20 million people worldwide suffer from focal drug-resistant epilepsy and are potential candidates for cure with epilepsy surgical interventions.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients with medication-refractory epilepsy - Planned intracranial EEG (IEEG) placement - Hypothesized to have temporal lobe epilepsy Who Should NOT Join This Trial: - Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients with medication-refractory epilepsy * Planned intracranial EEG (IEEG) placement * Hypothesized to have temporal lobe epilepsy Exclusion Criteria: * Contraindication to 3T MRI (e.g. metal implants or claustrophobia), clinical features that typically preclude the use of IEEG (e.g. pregnancy), prior intracranial surgery or device, and IEEG findings that are non-diagnostic (e.g. seizure onset zone(s) not identified)

Treatments Being Tested

DIAGNOSTIC_TEST

3T Magnetic Resonance Imaging

Magnetic resonance imaging acquired at a field strength of 3 Tesla.

DIAGNOSTIC_TEST

Intracranial electroencephalography recordings

Epilepsy patients may undergo implantation of intracranial electroencephalography (iEEG) electrodes for localization of epileptogenic foci, which also provide a means to record localized brain activity during memory or other tasks for research purposes.

DIAGNOSTIC_TEST

7T Magnetic Resonance Imaging

Magnetic resonance imaging acquired at a field strength of 7 Tesla.

Locations (1)

University of Pennsylvania
Philadelphia, Pennsylvania, United States