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RECRUITINGINTERVENTIONAL

Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences

Spinal Cord Lesion Detection in Multiple Sclerosis Using Novel MRI Sequences: A Pilot Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study is to evaluate the sensitivity and intra-/inter-observer agreement of the averaged magnetization inversion recovery acquisitions (AMIRA) in spinal cord (SC) Multiple sclerosis (MS) lesion detection and to evaluate the additional clinical value of this sequence in clinical settings.

Who May Be Eligible (Plain English)

Who May Qualify: - Diagnosis of multiple sclerosis according to established international criteria - Steroid free period: \> 4 weeks - Participation in the Swiss MS Cohort (SMSC) study Who Should NOT Join This Trial: - . History of severe (other) neurological, internal or psychiatric disease with SC affection - MRI-related exclusion criteria (questionnaire): 1. Paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the SC) 2. Pacemaker 3. Claustrophobia 4. Pregnancy, lactation 5. Known hypersensitivity to gadolinium-based contrast media Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Diagnosis of multiple sclerosis according to established international criteria * Steroid free period: \> 4 weeks * Participation in the Swiss MS Cohort (SMSC) study Exclusion Criteria: * . History of severe (other) neurological, internal or psychiatric disease with SC affection * MRI-related exclusion criteria (questionnaire): 1. Paramagnetic and/or superparamagnetic foreign objects in the body (especially when located close to the SC) 2. Pacemaker 3. Claustrophobia 4. Pregnancy, lactation 5. Known hypersensitivity to gadolinium-based contrast media

Treatments Being Tested

PROCEDURE

SC MRI

SC MRI (Averaged Magnetization Inversion Recovery Acquisitions (AMIRA), standard conventional SC MRI sequences, additional sequences for spinal cord MRI (sagittal-2D or 3D short tau inversion recovery, sagittal-2D or 3D phase-sensitive inversion recovery, 3D magnetization prepared 2 rapid acquisition gradient echoes (MPRAGE)). To evaluate the presences of ongoing inflammation (acute or chronic) in the SC of patients, 3D MPRAGE and 3D fluid-attenuated inversion recovery images after intravenous gadolinium (Gd) contrast administration (0.1 mmol per kg body weight) will be acquired.

OTHER

patient questionnaire

12-item multiple sclerosis walking scale (MSWS-12) questionnaire: self-report measure of the impact of MS on the individual's walking ability

Locations (1)

University Hospital Basel, Department of Neurology
Basel, Switzerland