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RECRUITINGPhase 3INTERVENTIONAL

Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The purpose of this study is to assess if preoperative treatment with Lugol's solution prior to thyroidectomy can reduce the surgical complications hypoparathyroidism and laryngeal nerve palsy

Who May Be Eligible (Plain English)

Who May Qualify: - Hyperthyroidism accepted for thyroidectomy due to toxic nodular goiter with free T4 \<30 pmol/L or Graves' disease - Signed willing to sign a consent form Who Should NOT Join This Trial: - Unstable coronary artery disease - Previous thyroid surgery - Congestive heart failure - Renal insufficiency - Hepatic failure - Current infection - Treatment with steroids or anticoagulants - Thyroid associated orbitopathy CAS \> 2 - Diabetes mellitus type 1 - Active cancer - Severe psychiatric illness - Amiodarone treatment - Pregnancy - Breast feeding - Women of child bearing potential not using contraceptive - Inability to comprehend the meaning of the study - Iodine hypersensitivity Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Hyperthyroidism accepted for thyroidectomy due to toxic nodular goiter with free T4 \<30 pmol/L or Graves' disease * Signed informed consent Exclusion Criteria: * Unstable coronary artery disease * Previous thyroid surgery * Congestive heart failure * Renal insufficiency * Hepatic failure * Current infection * Treatment with steroids or anticoagulants * Thyroid associated orbitopathy CAS \> 2 * Diabetes mellitus type 1 * Active cancer * Severe psychiatric illness * Amiodarone treatment * Pregnancy * Breast feeding * Women of child bearing potential not using contraceptive * Inability to comprehend the meaning of the study * Iodine hypersensitivity

Treatments Being Tested

DRUG

Iodine-Potassium Iodide 5%-10% Oral and Topical Solution

Iodine Potassium Iodide 5% oral solution, administered 3 times per day for 10 days

Locations (1)

Department of Endocrinology, Karolinska University Hospital
Solna, Stockholm County, Sweden