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RECRUITINGINTERVENTIONAL

Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder

A Randomized Control Trial of Bilateral Lateral OFC rTMS in Obsessive Compulsive Disorder

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

According to the literature the lateral part of the Orbito Frontal Cortex (lOFC) is a relevant bilateral target for repetitive Trans-cranial Magnetic Stimulation (rTMS) in Obsessive Compulsive Disorder (OCD). Both hemispheres are concerned in terms of target.

Who May Be Eligible (Plain English)

Who May Qualify: - Age: Participants will be both males and females, 18-65 years of age included. - diagnosis of OCD - all the patients must have failed to respond to at least two different pharmacological treatment used for at least 6 weeks - Affiliation to a social security system (recipient or assignee), - Signed written inform consent form Who Should NOT Join This Trial: - The exclusion criteria are a diagnosis of another psychiatric disorder (except for anxious disorders), a diagnosis of a significant active medical illness, pregnancy or other neurological illness - In accordance with the safety criteria for rTMS, patients with a history of seizure or bearing pacemakers, mobile metal implants, implanted medical pumps, or metal clips placed inside the skull will also be excluded - The patients won't be allowed to change their medication during the trial. The treatment must be stable at least 3 week before day 0. - Female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing, - Patient under curators - Patient hospitalized under duress - Patient unable to give his or hers willing to sign a consent form Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age: Participants will be both males and females, 18-65 years of age included. * diagnosis of OCD * all the patients must have failed to respond to at least two different pharmacological treatment used for at least 6 weeks * Affiliation to a social security system (recipient or assignee), * Signed written inform consent form Exclusion Criteria: * The exclusion criteria are a diagnosis of another psychiatric disorder (except for anxious disorders), a diagnosis of a significant active medical illness, pregnancy or other neurological illness * In accordance with the safety criteria for rTMS, patients with a history of seizure or bearing pacemakers, mobile metal implants, implanted medical pumps, or metal clips placed inside the skull will also be excluded * The patients won't be allowed to change their medication during the trial. The treatment must be stable at least 3 week before day 0. * Female subject who is pregnant, or of child-bearing age, sexually active and not using reliable contraception or who is nursing, * Patient under curators * Patient hospitalized under duress * Patient unable to give his or hers informed consent

Treatments Being Tested

DEVICE

rTMS Treatment

1 Hz rTMS

Locations (2)

Sorbonne University, Pitié-Salpêtrière Hospital
Paris, France
Centre Hospitalier Henri Laborit
Poitiers, France