Biperiden Trial for Epilepsy Prevention

Who May Qualify: - Given willing to sign a consent form - 18 - 75 years of age - GCS between 6 and 12 at hospital admission. GCS between 3 and 5 at hospital admission can be enrolled if patient was sedated at the accident scene with previous GCS between 6 and 15. - Moderate or severe acute traumatic brain injury - All genders - Brain CT scan with signs of of acute intraparenchymal hemorrhage and/or contusion - Able to receive the first dose of treatment or placebo within 18 hours of brain injury, Who Should NOT Join This Trial: - Previous use of biperiden - History of epilepsy (confirmed by patient chart) - History of seizures or use of antiepileptic medication - Pregnancy - Participation in another clinical trial at the time of randomization - History of neoplasia, neurodegenerative diseases; history of stroke, cognitive impairment, benign prostatic hyperplasia, atrioventricular block or any other cardiac arrhythmia, or glaucoma megacolon or mechanical obstruction - Homeless patient Always talk to your doctor about whether this trial is right for you.