RECRUITINGOBSERVATIONAL
Impact of Chemotherapy on Urinary Biomarkers and Non-Invasive Urodynamics in Children
About This Trial
The over-arching aim of this study is to evaluate the effects of two specific anti-cancer chemotherapies, vincristine and doxorubicin, on bladder function and urine composition.
Who May Be Eligible (Plain English)
Who May Qualify:
- Children aged 5-13 years old
- A history of cancer
- Treatment with a chemotherapy regimen including VCR and/or DOX
- Completion of chemotherapy at least one year prior to study enrollment and survey completion.
Who Should NOT Join This Trial:
- Patients with a:
- Primary pelvic tumor
- Pelvic irradiation
- Pre-existing bladder/bowel dysfunction
- Spinal defects
- Neurologic disorder
- Neuro-oncologic tumor or brain metastasis
- Cyclophosphamide or ifosfamide therapy
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Children aged 5-13 years old
* A history of cancer
* Treatment with a chemotherapy regimen including VCR and/or DOX
* Completion of chemotherapy at least one year prior to study enrollment and survey completion.
Exclusion Criteria:
* Patients with a:
* Primary pelvic tumor
* Pelvic irradiation
* Pre-existing bladder/bowel dysfunction
* Spinal defects
* Neurologic disorder
* Neuro-oncologic tumor or brain metastasis
* Cyclophosphamide or ifosfamide therapy
Treatments Being Tested
DIAGNOSTIC_TEST
Non-invasive Urodynamic Test (niUDS)
A noninvasive urodynamics is a simple test used to evaluate urinary flow.
DIAGNOSTIC_TEST
Urinary proteomic screen
Urine proteomics is a powerful platform to identify urinary excreted proteins and peptides in different stages of disease or therapy and to determine their quantity, functions, and interaction.
OTHER
Dysfunctional Voiding Symptom Score Survey (DVSS)
The Dysfunctional Voiding Symptom Score provides accurate and objective grading of voiding behaviors of children.
Locations (1)
Children's Hospital Colorado
Aurora, Colorado, United States