RECRUITINGPhase 4INTERVENTIONAL
Postpartum Hypertension Study
Oral Nifedipine Versus Intravenous Labetalol for Postpartum (PP) Hypertensive Emergency: A Randomized Clinical Trial (RCT)
About This Trial
The purpose of this study is to assess which blood pressure medication (intravenous labetalol or oral nifedipine) works better in treating severely elevated blood pressure in women who have just delivered a baby.
Who May Be Eligible (Plain English)
Inclusion criteria
- Patients admitted to labor and delivery (L\&D) with blood pressure (BP) in severe range, defined as a systolic ≥160 mm Hg and/or diastolic ≥110 mm Hg
- Postpartum, immediately to 6 weeks postpartum
- With a prior diagnosis of chronic hypertension (not on medication) or hypertensive disorder of pregnancy
Exclusion criteria
- They may not have previously had exposure to either study medication within the previous 24-hour period.
- Patients with a known atrial-ventricular heart block or moderate to severe bronchial asthma will be excluded, or other contraindication to receiving either study medication
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion criteria
* Patients admitted to labor and delivery (L\&D) with blood pressure (BP) in severe range, defined as a systolic ≥160 mm Hg and/or diastolic ≥110 mm Hg
* Postpartum, immediately to 6 weeks postpartum
* With a prior diagnosis of chronic hypertension (not on medication) or hypertensive disorder of pregnancy
Exclusion criteria
* They may not have previously had exposure to either study medication within the previous 24-hour period.
* Patients with a known atrial-ventricular heart block or moderate to severe bronchial asthma will be excluded, or other contraindication to receiving either study medication
Treatments Being Tested
DRUG
Labetalol
Intravenous labetalol, a short acting ant-hypertensive
DRUG
Nifedipine
Oral nifedipine, a short acting ant-hypertensive
Locations (1)
Columbia University Irving Medical Center
New York, New York, United States