RECRUITINGINTERVENTIONAL

Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome

Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome, With and Without CPAP, During Wakefulness - Impact on Cognitive Functions

About This Trial

The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a mechanical load on inspiration. UA collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity during wakefulness. The objective of this study is to test whether awake OSAS patients would exhibit a similar cortical activity. Whether or not such cortical compensatory mechanisms have cognitive consequences would be also analyze.

Who May Be Eligible (Plain English)

Inclusion criteria : 1. OSAS patients - severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h - without CPAP treatment 2. Non-OSAS patients - absence of OSAS (AHI \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11) Non-inclusion criteria : - \< 18 years old - \>75 years old - left-handed - BMI\> 40 kg/m² - another sleep disorder - central component of sleep apnea syndrome (central apnea index\> 5 / h) - current or past neurological pathology - respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia) - MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.) - taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.), - uncorrected sensory impairment (vision or hearing) - protected by law. Exclusion criteria : - pregnant woman according to the positive beta-hCG test result - left-handed following the laterality questionnaire - MINI results showing: - a current mood episode - a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco) - an eating disorder - a diagnosis of bipolar disorder, current or past schizophrenia Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion criteria : 1. OSAS patients * severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h * without CPAP treatment 2. Non-OSAS patients * absence of OSAS (AHI \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11) Non-inclusion criteria : * \< 18 years old * \>75 years old * left-handed * BMI\> 40 kg/m² * another sleep disorder * central component of sleep apnea syndrome (central apnea index\> 5 / h) * current or past neurological pathology * respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia) * MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.) * taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.), * uncorrected sensory impairment (vision or hearing) * protected by law. Exclusion criteria : * pregnant woman according to the positive beta-hCG test result * left-handed following the laterality questionnaire * MINI results showing: * a current mood episode * a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco) * an eating disorder * a diagnosis of bipolar disorder, current or past schizophrenia

Treatments Being Tested

DIAGNOSTIC_TEST

functional magnetic resonance imaging

Locations (1)

Chu Reims

Reims, France