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RECRUITINGINTERVENTIONAL

Depth Electrode Detection of Cortical Spreading Depolarization After Traumatic Brain Injury

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Preliminary evaluation of depth electrode recording and novel algorithms to determine Cortical Spreading Depolarization's (CSD) following traumatic brain injury (TBI) requiring neurosurgical intervention.

Who May Be Eligible (Plain English)

Who May Qualify: - Patient recommended to undergo EVD placement for the monitoring and possible treatment of Intracranial pressure (ICP) after TBI Who Should NOT Join This Trial: - Contaminated scalp lacerations - Known systemic infection - Non-English speaking - Fixed, uncorrectable coagulopathy Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patient recommended to undergo EVD placement for the monitoring and possible treatment of Intracranial pressure (ICP) after TBI Exclusion Criteria: * Contaminated scalp lacerations * Known systemic infection * Non-English speaking * Fixed, uncorrectable coagulopathy

Treatments Being Tested

DEVICE

depth electrodes

The study will be conducted at a single center, in TBI patients requiring neurosurgical intervention in the form of EVD placement. During neurosurgical intervention at the bedside in the Intensive Care Unit (ICU), a single depth electrode will be placed in the brain adjacent to the EVD catheter in the same burr hole. After EVD and depth electrode placement, continuous recording of ECoG activity as well as relevant physiological parameters will be performed for the duration of clinically indicated invasive neuromonitoring in accordance with the standard of care for TBI patients. A single recording station is currently available for data collection, therefore, with an anticipated average recording period of 14 days, the study will take greater than 210 days to complete for a total of 15 patients.

Locations (1)

Hennepin County Medical Center
Minneapolis, Minnesota, United States