RECRUITINGOBSERVATIONAL

A Prospective Cluster-Randomized, Controlled Crossover Trial to Validate an Electronic "Resistance Calculator"

Prospective Validation of the "Shamir Resistance Calculator": an Interventional Crossover Trial to Improve Empiric Prescription of Antimicrobials in Acute Care Hospitals.

About This Trial

Primary objective: \- Our aim is to validate the "Shamir Resistance Calculator" in a prospective crossover trial, in order to shorten the time to initiation of appropriate antimicrobials among hospitalized septic patients. Secondary objectives: \- To evaluate the impact of using the "Shamir Resistance Calculator" with regards to: * new acquisitions of multi-drug resistant organisms (MDRO) * the empiric usage of broad-spectrum agents (e.g., carbapenems, vancomycin) * acute Clostridiodes difficile infections * In-hospital mortality.

Who May Be Eligible (Plain English)

Who May Qualify: - Adult patients (age\>18 years) - Patients who are hospitalized at Shamir MC or at Hadassah Medical Organization during the study period. o Patients admitted to the ER and later-on discharged home, or discharged from the ER to a different facility, will be excluded as it will not enable us to follow all the designated outcomes. - Patients for which antibiotic treatment was initiated, empirically, due to acute sepsis. - Patients for which antibiotics were initiated as part of a main-consolidative regimen, or as part of a pre-emptive regimen, will not be included in the study. - Sepsis will be defined in accordance to established criteria1. Who Should NOT Join This Trial: \- Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Adult patients (age\>18 years) * Patients who are hospitalized at Shamir MC or at Hadassah Medical Organization during the study period. o Patients admitted to the ER and later-on discharged home, or discharged from the ER to a different facility, will be excluded as it will not enable us to follow all the designated outcomes. * Patients for which antibiotic treatment was initiated, empirically, due to acute sepsis. * Patients for which antibiotics were initiated as part of a main-consolidative regimen, or as part of a pre-emptive regimen, will not be included in the study. * Sepsis will be defined in accordance to established criteria1. Exclusion Criteria: \-

Treatments Being Tested

OTHER

Shamir Resistance Calculator

An on-line calculator which is free and accessible from all devices, which may predict the risk of MDRO infection upon admission, and the risk of nosocomial XDRO infection during the hospitalization. The calculator contains only parameters that could be extracted bedside, at the first presentation of a septic patient, including the ability to conduct a complete assessment also among patients with reduced consciousness and/or cognition.

Locations (2)

Shamir Medical Center (Assaf Harofeh)

Be’er Ya‘aqov, Israel

Hadassah Medical Organization

Jerusalem, Israel