RECRUITINGPhase 3INTERVENTIONAL
Tranexamic Acid in Traumatic Brain Injury
The Impact of Early Use of Tranexamic Acid in Traumatic Brain Injury Upon the Inflammatory Response and Outcome
About This Trial
In this study, our aim is to investigate the role of tranexamic acid for modulating the inflammation in patients with traumatic brain injury (TBI).
Who May Be Eligible (Plain English)
Who May Qualify:
- Isolated traumatic brain injury patients (mild or moderate cases)
- GCS \> 8
- non penetrating TBI in 8 hours onset
- Age ≥ 18 years
Who Should NOT Join This Trial:
- Patient in cardiac arrest
- Patients with coagulopathies
- Renal failure patients
- pregnancy
- Patient refusal to participate
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Isolated traumatic brain injury patients (mild or moderate cases)
* GCS \> 8
* non penetrating TBI in 8 hours onset
* Age ≥ 18 years
Exclusion Criteria:
* Patient in cardiac arrest
* Patients with coagulopathies
* Renal failure patients
* pregnancy
* Patient refusal to participate
Treatments Being Tested
OTHER
Saline
Giving saline (loading dose of 1gm of saline 0.9%, followed by a 1gm of maintenance saline dose over 8 hours for 48 h).
DRUG
Tranexamic acid
Giving TXA (loading dose of 1gm of TXA, followed by a 1gm of maintenance dose over 8 hours for 48 h).
Locations (1)
Assiut university hospital
Asyut, Assuit, Egypt