cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

Case Who May Qualify: - Newly diagnosed (within 120 days) with cancer or a recurrence of a cancer diagnosed \>5 years ago of one of the following subtypes: Invasive Brain, Breast, Bladder, Cervical, Colorectal, Endometrial, Esophageal, Gastric, Head and Neck, Hepatobiliary, Lung, Ovarian, Pancreatic, Prostate, Renal, Sarcoma, Thyroid; Leukemia, Lymphoma, Multiple Myeloma - Able and willing to provide willing to sign a consent form - ≥40 years of age Case Who Should NOT Join This Trial: - Currently receiving any treatment for cancer - Currently taking any demethylating agents/DNA hypomethylating agents - Simultaneously diagnosed with two or more invasive cancers - Diagnosed with any invasive or non-invasive cancer in addition to the index cancer in the last 5 years - Currently diagnosed with any chronic hematopoietic cancer (e.g. chronic CLL) in addition to the index cancer - Currently diagnosed with any myelodysplastic syndromes and/or precursor hematologic conditions (e.g. MGUS) in addition to the index cancer - Women who are known to be pregnant (self-reported) Control Inclusion Criteria - Not diagnosed with any cancer in the last 5 years (non-invasive cancer is allowed) - Able and willing to provide willing to sign a consent form - ≥40 years of age Control Exclusion Criteria - Currently receiving any treatment for cancer - Currently taking any demethylating agents/DNA hypomethylating agents - Women who are known to be pregnant (self-reported) Always talk to your doctor about whether this trial is right for you.