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RECRUITINGINTERVENTIONAL

Diagnostic Yield of Intranodal Forceps Biopsies in Mediastinal Adenopathy

Evaluating the Diagnostic Yield and Specimen Quality With Endobronchial Ultrasound-Guided Intranodal Forceps Biopsies in Patients With Mediastinal and Hilar Lymphadenopathy: A Prospective Analysis

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The investigators will compare endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) with intranodal forceps biopsy (EBUS-IFB) as it relates to the rate of diagnosis of suspected sarcoidosis.

Who May Be Eligible (Plain English)

Who May Qualify: - Radiologic evidence of mediastinal and/or hilar lymphadenopathy - Attending radiologist or pulmonologist reports a possible diagnosis of sarcoidosis - Age 18 years or older Exclusion Criteria\*: These are the characteristics that a participant must NOT have in order to be eligible to participate in the study. Order Number Criteria - Severe pulmonary hypertension - Inability to undergo general anesthesia - Severe coagulopathy or bleeding diathesis - Previously diagnosed sarcoidosis - Patient presently taking clopidogrel - Patient deemed to be high risk for general anesthesia per anesthesiologist - Hemodynamic instability - Mediastinitis - Acute Hypercarbic Respiratory Failure (pCO2 \>55mmHg) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Radiologic evidence of mediastinal and/or hilar lymphadenopathy * Attending radiologist or pulmonologist reports a possible diagnosis of sarcoidosis * Age 18 years or older Exclusion Criteria\*: These are the characteristics that a participant must NOT have in order to be eligible to participate in the study. Order Number Criteria * Severe pulmonary hypertension * Inability to undergo general anesthesia * Severe coagulopathy or bleeding diathesis * Previously diagnosed sarcoidosis * Patient presently taking clopidogrel * Patient deemed to be high risk for general anesthesia per anesthesiologist * Hemodynamic instability * Mediastinitis * Acute Hypercarbic Respiratory Failure (pCO2 \>55mmHg)

Treatments Being Tested

PROCEDURE

Endobronchial Ultrasound-Guided Intranodal Forceps Biopsy

Patients with mediastinal adenopathy will undergo EBUS-IFB and EBUS-TBNA during the same procedure to compare the yield of this procedure with EBUS-TBNA alone.

Locations (1)

The George Washington University Hospital
Washington D.C., District of Columbia, United States