A Randomised Controlled Trial of N-acetylcysteine for the Management of Alcohol Use Disorder

Who May Qualify: - Alcohol Use Disorder according to the DSM-V criteria - A desire to reduce or stop drinking - Consumed at least 21 standard drinks per week or 2 heavy drinking days per week (HDD: ≥ 5 standard drinks/day for men; ≥4 for women) in the month prior to screening - Adequate cognition and English language skills to give valid consent and complete research interviews - Stable housing - Willingness to give written willing to sign a consent form Who Should NOT Join This Trial: - Pregnancy or lactation (women will be advised to use reliable contraception during the trial and a pregnancy test will be performed were necessary) - Concurrent use of any psychotropic medication other than antidepressants (provided these are taken at stable doses for at least two months) - Any substance dependence other than nicotine - Clinically unstable systemic medical (e.g. cancer, end stage liver disease: e.g. MELD score ≥ 10) or psychiatric disorder (e.g. active psychosis, borderline personality disorder, active suicide risk: e.g. MADRAS item 10 score of 6) that precludes trial participation - Concurrent use of selenium, vitamin D or other anti-oxidants - Any alcohol pharmacotherapy within the past month Always talk to your doctor about whether this trial is right for you.