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RECRUITINGINTERVENTIONAL

Neural Connectivity During Therapy for Adolescent PTSD

Neural Connectivity Before and After Each of the Three Treatment Phases of Trauma-focused Therapy for Adolescent Posttraumatic Stress

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Posttraumatic stress disorder in adolescence impairs neurobiological networks underlying cognitive, social and emotional skills. Neuroimaging research that seeks to identify the neural mechanisms of treatments for PTSD could lead to novel treatments, but progress has been slow using current methods. The proposed study uses an innovative approach to identify neural mechanisms of specific phases of trauma-focused therapy for youth with PTSD, allowing a new understanding of brain changes associated with the process of therapy.

Who May Be Eligible (Plain English)

Who May Qualify: - ages 12-17 and Tanner stage 2 or above - history of interpersonal trauma - PTSD symptoms with a rating of '2' or higher on at least one symptom from each of the 4 clusters, using the Clinician-Administered PTSD Scale for Children and Adolescents, and having a duration of at least one month Who Should NOT Join This Trial: - current or past use of psychiatric medications - severe suicidal/homicidal ideation - current hospitalization - other current psychotherapy or previous treatment with TF-CBT - history of head injury with loss of consciousness for \>5 minutes - IQ\<85 - major medical illness - MRI contraindications (metal in body; braces on teeth) - psychosis, bipolar 1, autism, developmental disorder, panic disorder - first-degree family member with diagnosis of psychosis or bipolar I disorder - substance dependence within the past 3 months or current drug use that is frequent Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * ages 12-17 and Tanner stage 2 or above * history of interpersonal trauma * PTSD symptoms with a rating of '2' or higher on at least one symptom from each of the 4 clusters, using the Clinician-Administered PTSD Scale for Children and Adolescents, and having a duration of at least one month Exclusion Criteria: * current or past use of psychiatric medications * severe suicidal/homicidal ideation * current hospitalization * other current psychotherapy or previous treatment with TF-CBT * history of head injury with loss of consciousness for \>5 minutes * IQ\<85 * major medical illness * MRI contraindications (metal in body; braces on teeth) * psychosis, bipolar 1, autism, developmental disorder, panic disorder * first-degree family member with diagnosis of psychosis or bipolar I disorder * substance dependence within the past 3 months or current drug use that is frequent

Treatments Being Tested

BEHAVIORAL

TF-CBT

evidence-based psychotherapy for trauma in youth

BEHAVIORAL

TAU

treatment as usual

Locations (1)

UT Health Department of Psychiatry
San Antonio, Texas, United States