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RECRUITINGINTERVENTIONAL

Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety

Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety: A Randomized Clinical Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety. CGRI aims to raise end-tidal CO2 levels thereby lowering hyperventilation-induced respiratory alkalosis and its associated fear-eliciting somatic reactions. Psycho-education about anxiety and its effects (PsyEd) will serve as a credible control comparator.

Who May Be Eligible (Plain English)

Who May Qualify: 1. Clinically elevated anxiety as indicated by an eight or higher on the Overall Anxiety Severity and Impairment Scale (OASIS). 2. Meets DSM-5 criteria for one or more of the following anxiety or trauma-related disorders as their "primary" mental disorder: - Generalized Anxiety Disorder - Panic Disorder - Health Anxiety - Agoraphobia - Social Anxiety Disorder - Posttraumatic Stress Disorder - Acute Stress Disorder - Adjustment Disorder with primary anxious mood - Anxiety disorder not otherwise specified 3. No current use of psychotropic medications or stable on current medications for at least 6 weeks 4. Age 18+. 5. Able to arrange transportation to our laboratory for study appointments. 6. Fluent in English. Who Should NOT Join This Trial: 1. No history of medical conditions that would contraindicate participation in fear-provocation or respiratory challenges, including: - Cardiovascular or respiratory disorders - High blood pressure - Epilepsy - Strokes - Seizures - History of fainting - Pregnant or lactating 2. Not currently receiving other psychological treatment for anxiety. 3. No history of a suicide attempt within the past 6 months. 4. No history of psychosis within the past 6 months. 5. No history of moderate to severe alcohol or substance use disorder (with the exception of nicotine) within the past 3 months. 6. Does not endorse COVID-19 symptoms during the screening phase. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Clinically elevated anxiety as indicated by an eight or higher on the Overall Anxiety Severity and Impairment Scale (OASIS). 2. Meets DSM-5 criteria for one or more of the following anxiety or trauma-related disorders as their "primary" mental disorder: * Generalized Anxiety Disorder * Panic Disorder * Health Anxiety * Agoraphobia * Social Anxiety Disorder * Posttraumatic Stress Disorder * Acute Stress Disorder * Adjustment Disorder with primary anxious mood * Anxiety disorder not otherwise specified 3. No current use of psychotropic medications or stable on current medications for at least 6 weeks 4. Age 18+. 5. Able to arrange transportation to our laboratory for study appointments. 6. Fluent in English. Exclusion Criteria: 1. No history of medical conditions that would contraindicate participation in fear-provocation or respiratory challenges, including: * Cardiovascular or respiratory disorders * High blood pressure * Epilepsy * Strokes * Seizures * History of fainting * Pregnant or lactating 2. Not currently receiving other psychological treatment for anxiety. 3. No history of a suicide attempt within the past 6 months. 4. No history of psychosis within the past 6 months. 5. No history of moderate to severe alcohol or substance use disorder (with the exception of nicotine) within the past 3 months. 6. Does not endorse COVID-19 symptoms during the screening phase.

Treatments Being Tested

DEVICE

Capnometry-Guided Respiratory Intervention

See: Arm/group descriptions

BEHAVIORAL

Psycho-Education

See: Arm/group descriptions

Locations (1)

University of Texas at Austin
Austin, Texas, United States