Measures of Respiratory Health Registry

Participants with CF Who May Qualify: -Diagnosis of CF as evidenced by one or more clinical feature consistent with the CF phenotype or positive CF newborn screen AND one or more of the following criteria: i. A documented sweat chloride ≥ 60 mEq/L by quantitative pilocarpine iontophoresis (QPIT). ii. A documented genotype with two disease-causing mutations in the CFTR gene. \- In the opinion of the investigator, the participant will likely have the ability to perform the lung function test of interest on the day of testing Who Should NOT Join This Trial: - Physical findings at the screening that would compromise the safety of the participant or the quality of the data (e.g. respiratory distress or work of breathing) - Requirement of supplementary oxygen to maintain oxygen saturation above 95% Participants with other Respiratory Disease Who May Qualify: - Physician-diagnosed lung disease - willing to sign a consent form by participant, parent, or legal guardian - In the opinion of the investigator, the participant will likely have the ability to perform the lung function test of interest on the day of testing Exclusion criteria - Physical findings at screening that would compromise the safety of the participant or the quality of the research data - Requirement of supplementary oxygen to maintain oxygen saturation above 95% Healthy Participants - Inclusion criteria - willing to sign a consent form by participant, parent, or legal guardian - In the opinion of the investigator, the participant will likely have the ability to perform the lung function test of interest on the day of testing Exclusion criteria - Physical findings at screening that would compromise the safety of the participant or the quality of the research data - Evidence of lung disease Always talk to your doctor about whether this trial is right for you.