Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI

Who May Qualify: 1. Patients presenting with: - Symptoms of myocardial ischemia lasting for ≥ 30 minutes AND - Definite ECG changes indicating STEMI: ST elevation of greater than 0.1 mV in two contiguous limb leads or 0.2 mV in two contiguous precordial leads 2. Referred for PPCI 3. Within 12 hours of symptom onset, or 12-24 hours but still suffered from persistent symptom, hemodynamic instability or fatal arrhythmia 4. High thrombus burden: - TIMI thrombus grade 3 or 4 after emergency coronary angiography - Or TIMI thrombus grade ≥3 after guidewire crossing or 1.5mm-diameter predilating the culprit lesion if emergency coronary angiography shows TIMI thrombus grade 5 5. willing to sign a consent form Who Should NOT Join This Trial: 1. Rescue PCI after systemic thrombolysis 2. Previous CABG history 3. Life expectancy\<1 year 4. Active bleeding in past 6 months, hemorrhagic disorders and prone to bleeding 5. Serious hepatic or kidney dysfunction 6. Pregnancy and lactation 7. Uncontrolled hypertension (\>180/100mmHg) 8. Previous hemorrhagic stroke or ischemic stroke in past 3 months 9. Cardiogenic shock or cardio-pulmonary resuscitation 10. willing to sign a consent form cannot be obtained or follow-up cannot be completed Always talk to your doctor about whether this trial is right for you.