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RECRUITINGINTERVENTIONAL

Iodine Uptake After a Low Iodine Diet

The Uptake of Radioactive Iodine Before and After a Low Iodine Diet in Patients With Differentiated Thyroid Carcinoma

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this clinical trial is to compare the difference in thyroid uptake of a low dose radioactive iodine (10 MBq 123-I or 37 MBq 123-I) in athyreotic patients with differentiated thyroid carcinoma before and after a low iodine diet (LID) of 7 days. The main question it aims to answer is: • What is the difference in iodine uptake before and after a LID of 7 days? Uptake of a low dose of 123-iodine will be measured in participants before and after a low iodine diet of 7 days. Researchers will compare the uptake (%) before and after the LID.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients, men and women above the age of 18 years, have to be diagnosed with DTC and have to follow a LID prior to the 131I ablation therapy according to the Dutch DTC guideline - Patients have to be fit to adhere to the study protocol - Patients have to be able to read and understand the Dutch language Who Should NOT Join This Trial: - Age \< 18 years - Patients using amiodarone - Patients receiving iodinated contrast \< 3 months before the LID - Pregnancy - Patients prepared for ablation therapy with rhTSH - Renal impairment, EGFR \<30ml/min/1,73m2 Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Patients, men and women above the age of 18 years, have to be diagnosed with DTC and have to follow a LID prior to the 131I ablation therapy according to the Dutch DTC guideline * Patients have to be fit to adhere to the study protocol * Patients have to be able to read and understand the Dutch language Exclusion Criteria: * Age \< 18 years * Patients using amiodarone * Patients receiving iodinated contrast \< 3 months before the LID * Pregnancy * Patients prepared for ablation therapy with rhTSH * Renal impairment, EGFR \<30ml/min/1,73m2

Treatments Being Tested

BEHAVIORAL

Low iodine diet

Before ablation and possible subsequent therapy with 131I, patients have to follow a low iodine diet (LID), reducing the iodine intake \< 50 mcg per day and thereby depleting the overall iodine store in the body.

Locations (1)

UMCG
Groningen, Provincie Groningen, Netherlands