RECRUITINGOBSERVATIONAL
Gut Microbiome and Blood Indices in Patients With AD and Their Spousal Caregivers
About This Trial
Spousal caregivers of Alzheimer's Dementia (AD) patients have an elevated risk of developing AD in the future. Past studies have shown the presence of serum indicators correlated with gut biome dysfunction in AD patients. We hypothesize that the same gut biome dysfunction may be present in spousal caregivers of AD patients.
Who May Be Eligible (Plain English)
Who May Qualify:
1. patients with AD whose clinical dementia rating (CDR) is \> 1
2. Spouses of Patients in the above group Or
3. Healthy adult unrelated to groups 1 and 2, with no history of dementia And
4. Regardless of the grouping, the prospective subject must be between 65 and 90 years old
Who Should NOT Join This Trial:
1. Familial Alzheimer's Disease (AD)
2. Severe cardiovascular disease
3. Severe respiratory system disease
4. Severe liver disease
5. Severe kidney disease
6. Severe central nervous system diseases
7. Having a lifespan of fewer than 3 months
8. History of psychiatric illness
9. Major neurological diseases other than AD
10. Current use of corticosteroids, antibiotics, or bowel motility modification agents
11. Any history of Alcoholism or illicit drug dependence
12. Previous inclusion in this study
13. Difficulty with follow-up or poor compliance
14. Severe hearing impairment
15. Severe vision impairment
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
1. patients with AD whose clinical dementia rating (CDR) is \> 1
2. Spouses of Patients in the above group Or
3. Healthy adult unrelated to groups 1 and 2, with no history of dementia And
4. Regardless of the grouping, the prospective subject must be between 65 and 90 years old
Exclusion Criteria:
1. Familial Alzheimer's Disease (AD)
2. Severe cardiovascular disease
3. Severe respiratory system disease
4. Severe liver disease
5. Severe kidney disease
6. Severe central nervous system diseases
7. Having a lifespan of fewer than 3 months
8. History of psychiatric illness
9. Major neurological diseases other than AD
10. Current use of corticosteroids, antibiotics, or bowel motility modification agents
11. Any history of Alcoholism or illicit drug dependence
12. Previous inclusion in this study
13. Difficulty with follow-up or poor compliance
14. Severe hearing impairment
15. Severe vision impairment
Locations (1)
University of Virginia
Charlottesville, Virginia, United States