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RECRUITINGOBSERVATIONAL

Phenotyping Heterogeneity and Regionality of the Aorta

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aorta distributes cardiac stroke volume into the whole body through its finetuned conductance function, that is propagation and modulation of flow pattern. Physicomechanic properties of the aortic wall assure continuous and homogenous blood flow distribution to organs. The physicomechanic properties of the aortic wall are heterotopic: The collagen/elastin ratio doubles in the abdominal aorta as compared to the thoracic aorta. Malfunction of aortic conduction due to large artery stiffening (LAS) leads to premature wave reflection and excess pulsatility which translate into organ damage in low-resistance beds. The regional heterogeneity of aortic physicomechanic properties and their histomorphological substrate leading to altered regional hemodynamics are not well investigated. Within the PHaRAo population, there is a spectrum of higher and lower risk patients. The aim of this cohort study is to collect prospectively and systematically clinical research data from PHaRAo patients. This cohort study is an open-end observational study to identify master switches in aortic disease

Who May Be Eligible (Plain English)

1. apparently healthy volunteers Who May Qualify: • Healthy volunteers Who Should NOT Join This Trial: - \< 18 years - Active Medication - Cardiovascular Disease - MRI not possible 2. Patients with Aortic Stenosis Who May Qualify: • Patients suffering from 3rd drgree Aortic Stenosis Who Should NOT Join This Trial: - \< 18 years - MRI not possible 3. Patients with Aortic Aneurysms Who May Qualify: • Patients suffering from Aortic Aneurysms Who Should NOT Join This Trial: - \< 18 years - MRI not possible Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
1. apparently healthy volunteers Inclusion Criteria: • Healthy volunteers Exclusion Criteria: * \< 18 years * Active Medication * Cardiovascular Disease * MRI not possible 2. Patients with Aortic Stenosis Inclusion Criteria: • Patients suffering from 3rd drgree Aortic Stenosis Exclusion Criteria: * \< 18 years * MRI not possible 3. Patients with Aortic Aneurysms Inclusion Criteria: • Patients suffering from Aortic Aneurysms Exclusion Criteria: * \< 18 years * MRI not possible

Treatments Being Tested

OTHER

Collection of Clinical Data

prospectively and systematically collection of clinical research data from apparently healthy volunteers and patients with aortic stenosis and aneurysms

Locations (1)

Christine Quast
Düsseldorf, Germany