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RECRUITINGINTERVENTIONAL

Personalized B-fructan Diet in Inflammatory Bowel Disease Patients

The Fibre Study: RCT of Personalized Fibre Diet in IBD

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study aims to examine patient tolerability of personalized dietary fibre consumption recommendations (high-pectin diet versus high-B-fructan diet based on personalized responses), provided by an IBD dietician, based on our novel translational research findings.

Who May Be Eligible (Plain English)

Who May Qualify: - Children (age 6-17) or young adults (age 18-39). - Known or suspected UC or IBDU \[there will be 2 control group: non-IBD (undergoing colonoscopy but found not to have IBD; and healthy (no GI symptoms, so not required to have colonoscopy; could be family members)\] - For UC: Remission-mild-moderate disease: Mayo score \<10 - Clinical indication for sedated colonoscopy - Disease location: E2-E4 - Stable treatment (not on steroids; biologics or immunomodulator not changed in last month) - High likelihood that patients will be able to collect all samples and provide all data Who Should NOT Join This Trial: - Use of antibiotics for a week or more over the last 3 months - Use of probiotics or prebiotics at pharmacological doses (adding fibre sources to food or probiotics in yogurt, for example, are allowed) - History of abdominal surgery, including appendectomy - Documented enteric infection during the 3 months prior to endoscopy - Presence of non-IBD bowel conditions (e.g., celiac), anatomical or mucosal abnormalities, motility disorder - Presence of a systemic disease requiring treatment (cancer, ischemic heart disease, kidney failure, etc) - Proctitis (E1) - Systemic steroids (above 10 mg/day of Prednisone) - Topical therapy within 1 week of endoscopy - Recent change in IBD treatment (started biologics or IM over the last month) - Pregnancy or planning to become pregnant during the study - Inability to understand or sign the consent Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Children (age 6-17) or young adults (age 18-39). * Known or suspected UC or IBDU \[there will be 2 control group: non-IBD (undergoing colonoscopy but found not to have IBD; and healthy (no GI symptoms, so not required to have colonoscopy; could be family members)\] * For UC: Remission-mild-moderate disease: Mayo score \<10 * Clinical indication for sedated colonoscopy * Disease location: E2-E4 * Stable treatment (not on steroids; biologics or immunomodulator not changed in last month) * High likelihood that patients will be able to collect all samples and provide all data Exclusion Criteria: * Use of antibiotics for a week or more over the last 3 months * Use of probiotics or prebiotics at pharmacological doses (adding fibre sources to food or probiotics in yogurt, for example, are allowed) * History of abdominal surgery, including appendectomy * Documented enteric infection during the 3 months prior to endoscopy * Presence of non-IBD bowel conditions (e.g., celiac), anatomical or mucosal abnormalities, motility disorder * Presence of a systemic disease requiring treatment (cancer, ischemic heart disease, kidney failure, etc) * Proctitis (E1) * Systemic steroids (above 10 mg/day of Prednisone) * Topical therapy within 1 week of endoscopy * Recent change in IBD treatment (started biologics or IM over the last month) * Pregnancy or planning to become pregnant during the study * Inability to understand or sign the consent

Treatments Being Tested

OTHER

Placebo Comparator: Randomized pectin diet

UC and healthy control participants randomized to receive recommendations provided by a dietician increasing consumption of foods high in pectin

OTHER

Randomized B-fructan diet

UC and healthy control participants randomized to receive recommendations provided by a dietician increasing consumption of foods high in B-fructan

OTHER

Personalized pectin diet

UC and healthy control participants to receive recommendations provided by a dietician increasing consumption of foods high in pectin based on personal host (biopsy) and microbe (stool) response at baseline

OTHER

Personalized B-fructan diet

UC and healthy control participants to receive recommendations provided by a dietician increasing consumption of foods high in B-fructan based on personal host (biopsy) and microbe (stool) response at baseline

Locations (2)

University of Alberta Hospital
Edmonton, Alberta, Canada
Health Sciences Centre Hospital
Winnipeg, Manitoba, Canada