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RECRUITINGINTERVENTIONAL

Exercise to Improve Sleep in Parkinson's Disease

The Effects of Different Exercise Modalities on Sleep Quality and Architecture in People With Parkinson's Disease

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with Parkinson's disease (PD). Furthermore, the project will investigate whether the potential positive exercise-induced changes in sleep are associated with improvements in different quality of life (QoL)-related aspects. Participants will perform either cardiovascular training (CT), resistance training (RT), multimodal training (MT), or will be allocated to a control condition (i.e., waiting list - CON) for 12 weeks. Training will be performed three times/week. The assessments will be conducted at baseline, post-intervention, and follow-up (i.e. 8 weeks after the intervention) by assessors blinded to the participants' group allocation.

Who May Be Eligible (Plain English)

Who May Qualify: - Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn \& Yahr Scale stages 0.5-3.5); - On a stable dosage of medication during the previous month; - Having poor sleep quality defined as a score \> 15 in the PDSS-2 and/or reporting subjective sleep complaints affecting their sleep quality; Who Should NOT Join This Trial: - Having atypical parkinsonism, dementia, stroke, or any other neurological condition; - Presenting severe untreated obstructive sleep apnea (OSA); - Having a Montreal Cognitive Assessment (MoCA) score \<18 - Having a Beck Depression Inventory score \>31; - Having absolute contraindications to exercise; - Having severe osteoporosis; - Participating in an exercise or drug trial during the period of the study; - Exceeding the physical activity levels recommended for the general population (≥150 minutes/week of moderate-intensity or ≥75 minutes/week of vigorous-intensity cardiovascular activity) and/or strengthening activities ≥2 days/week. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Persons with mild-moderate idiopathic Parkinson's Disease (Modified Hoehn \& Yahr Scale stages 0.5-3.5); * On a stable dosage of medication during the previous month; * Having poor sleep quality defined as a score \> 15 in the PDSS-2 and/or reporting subjective sleep complaints affecting their sleep quality; Exclusion Criteria: * Having atypical parkinsonism, dementia, stroke, or any other neurological condition; * Presenting severe untreated obstructive sleep apnea (OSA); * Having a Montreal Cognitive Assessment (MoCA) score \<18 * Having a Beck Depression Inventory score \>31; * Having absolute contraindications to exercise; * Having severe osteoporosis; * Participating in an exercise or drug trial during the period of the study; * Exceeding the physical activity levels recommended for the general population (≥150 minutes/week of moderate-intensity or ≥75 minutes/week of vigorous-intensity cardiovascular activity) and/or strengthening activities ≥2 days/week.

Treatments Being Tested

BEHAVIORAL

Cardiovascular training (CT)

12 weeks of CT

BEHAVIORAL

Resistance training (RT)

12 weeks of RT

BEHAVIORAL

Multimodal training (MT)

12 weeks of MT

Locations (3)

Jewish Rehabilitation Hospital
Laval, Quebec, Canada
Human Brain Control of Locomotion Laboratory
Montreal, Quebec, Canada
Cummings Centre
Montreal, Quebec, Canada